PAS家族转录因子及其下游基因在大鼠肝再生中的作用  

Relevance analysis of the PAS domain transcription factor genes and their downstream genes with rat liver regeneration

作　　者：董华明[1] 李静[2] 徐存拴 

机构地区：[1]河南科技学院,河南新乡453003 [2]河南师范大学,河南新乡453007

出　　处：《河南科技学院学报》2009年第2期27-29,38,共4页Journal of Henan Institute of Science and Technology(Natural Science Edition)

基　　金：973计划前期专项(2006CB708506)

摘　　要：为在基因转录水平了解PAS结构域转录因子家族基因及它们的下游基因在肝再生(liver regeneration,LR)中作用,本文用Rat Genome 230 2.0芯片检测上述基因在大鼠再生肝中表达情况,用真、假手术比较方法确定肝再生相关基因。初步证实25个基因与肝再生相关,它们在促进再生肝细胞分化及异源物、糖、脂代谢,促进肝再生早期的免疫反应和后期的血管发生中发挥作用。To study the relevance of the PAtS domain transcription factor genes and their downstream target genes with liver regeneration （LR） at transcriptional level,the gene expression changes in rat regenerating livers were checked utilizing the Rat Genome 230 2.0 array. The LR-associated genes were identified by comparing differences in gene expression between partial hepateetomy （pH） and sham operation （SO）. It was found that above 25 genes were associated with liver regeneration,and they played the roles in promoting hepatocyte differentiation and metabolism of xenobiotic, carbohydrates and lipid in regenerating liver, and improvement of immune response in forepart and angiogenesis in anaphase of LR.

关 键 词：部分肝切除 Rat GENOME 230 2.0芯片 PAS结构域家族转录因子 肝再生相关基因 

分 类 号：Q291[生物学—细胞生物学]