医用316L不锈钢支架表面磁性膜对血管内皮化的影响  

The Effect of Superficial Magnetic Films of 316L Medical Steel Stents on Endothelialization

作　　者：胡涛[1,2,3] 于振涛[1] 周廉[1] 介万奇[2] 周景昱[3] 王海昌[3] 

机构地区：[1]西北有色金属研究院,陕西西安710016 [2]西北工业大学,陕西西安710049 [3]第四军医大学西京医院,陕西西安710032

出　　处：《稀有金属材料与工程》2009年第9期1552-1555,共4页Rare Metal Materials and Engineering

基　　金：国家自然科学基金(30470486);中国博士后科学基金面上资助金(20070410383);中国博士后科学基金特别资助金(200801439)

摘　　要：研究了表面磁性膜医用316L不锈钢支架对血管内皮化的影响。通过体外内皮细胞培养和支架粘附内皮细胞的实验来观察体外支架内皮化的情况;并通过动物体内支架植入实验观察评价血管内皮覆盖及血小板粘附及激活情况。结果表明:表面磁性膜支架在体外可以促进内皮细胞的粘附、增殖,支架植入后在体内可以促进血管内皮再生,加速支架内皮化,同时抑制血小板粘附及激活。The effect of superficial magnetic film on vascular endothelialization for the 316L medical stainless steel stent was investigated in this study. The in vitro endothelial response of human umbilical vein endothelium cell （HUVECs） was investigated on the superficial magnetic film 316L medical stainless steel stent vs bare-metal stent surface; as well as the re-endothelialization and platelet adhesion reaction of superficial magnetic film 316L medical stainless steel stent vs bare-metal stent were evaluated with SEM after animal models implantation for 1 month and 3 months. The consequence indicates that the superficial magnetic film 316L medical stainless steel stent can increase the adhesion and proliferation of HUVECs in vitro, and promote the regenesis of vas endothelialization after implantation in vivo, as well as speed the stent endothelialization and inhibite the platelet adhesion reaction and activation, simultaneously.

关 键 词：血管内皮化 磁性薄膜 316L不锈钢支架 

分 类 号：TG142.71[一般工业技术—材料科学与工程]