5-氰基脲嘧啶类化合物的合成及其强心活性研究(Ⅱ)  

Synthesis and Cardiac Activity of 5 Cyanouracil Derivatives(Ⅱ)

作　　者：王礼琛[1] 刘保林[1] 任进知[1] 李家璇 徐志强 

机构地区：[1]中国药科大学有机化学教研室

出　　处：《中国药科大学学报》1998年第4期251-254,共4页Journal of China Pharmaceutical University

基　　金：江苏省自然科学基金

摘　　要：设计合成了９个５－氰基脲嘧啶类化合物，经红外光谱、核磁共振谱及质谱证实了其化学结构。初筛实验表明，大部分化合物具有强心活性。Nine 5 cyanouracil derivatives were designed and synthesized of which all were not reported previously. Their structures were identified by IR, 1HNMR and MS. In preliminary biological test, some of the compounds showed varied cardiac activities, the best one is compound Ⅳ f.

关 键 词：氰基脲嘧啶 心肌收缩 合成 强心药 

分 类 号：TQ463.53[化学工程—制药化工] R972.1[医药卫生—药品]