丹参二萜醌的结构修饰  

Modification of Diterpenoid Quinones from Salvia miltiorrhiza

作　　者：杨东[1] 罗厚蔚[1] 

机构地区：[1]中国药科大学植物化学教研室

出　　处：《中国药科大学学报》1998年第4期255-258,共4页Journal of China Pharmaceutical University

摘　　要：为了改善丹参脂溶性成分丹参酮Ⅰ和丹参酮Ⅱ－Ａ的溶解性及生物活性，以这两种化合物为先导化合物，结合计算机辅助分子结构模拟研究，通过Ｍａｎｎｉｃｈ反应共合成了１５个衍生物。其中１４个化合物未见报道。In order to improve the solubility and bioactivity of danshinone Ⅰ and danshinone Ⅱ A, from Dan Shen( Salvia miltiorrhiza Bunge), a kind of Chinese medicine, fifteen derivatives from the leading compounds danshinone Ⅰ and danshinone Ⅱ A based on the result of computer assisted modeling study, were synthesized by Mannich reaction. Fourteen compounds of them were not reported previously and the structures were identified by elemental analysis, MS and 1HNMR spectra.

关 键 词：丹参 MANNICH反应 丹参酮 二萜醌 结构修饰 

分 类 号：R284[医药卫生—中药学]