脂蛋白脂酶基因多态性与冠心病关系的初探  

Initial study on the association of lipoprotein lipase (LPL) gene polymorphisms with coronary heart disease (CHD)

作　　者：钱卫冲[1] 王强[1] 朱铁兵[1] 王震震[1] 王连生[1] 王海燕[1] 杜福昌[1] 徐希平 

机构地区：[1]南京医科大学第一附属医院心脏科

出　　处：《中华心血管病杂志》1998年第4期309-312,共4页Chinese Journal of Cardiology

摘　　要：目的探讨脂蛋白脂酶（ＬＰＬ）基因多态性与冠心病的关系。方法选择１０６例住院存活的心肌梗塞病人按１∶１进行病例对照研究，采用条件Ｌｏｇｉｓｔｉｃ回归分析。结果吸烟、ＬＰＬ基因型ＰＶＵⅡ（－－）和单倍体基因型Ｈ＋Ｐ－是冠心病独立的危险因素；高密度脂蛋白胆固醇（ＨＤＬ－Ｃ）和载脂蛋白（Ａｐｏ）Ａ／Ｂ比值是冠心病的保护因素。去除其它因素的影响后，ＬＰＬＰＶＵⅡ（－－）／非（－－）和Ｈ＋Ｐ－／非Ｈ＋Ｐ－的ＯＲ值为１７．１８和３．６７；ＨＤＬ－Ｃ、ＡｐｏＡ／Ｂ比值的ＯＲ值在模型Ａ和Ｂ中分别为０．１４、０．１５和０．０４、０．０９。结论除传统的危险因素外，ＬＰＬ基因型ＰＶＵⅡ（－－）和单倍体Ｈ＋Ｐ－可能是易患冠心病的遗传标志；ＨＤＬ－Ｃ。Objective To explore the association of LPL gene polymorphisms with CHD. Methods 106 patients in myocardial infarction survivors were analyzed through a casecontrol study. Results The conditional logistic regression analysis demonstrated that 5 factors were associated with CHD. The risk factors were smoking, LPL genotype PVUⅡ(--) and haplotype H+P-, while high density lipoprotein cholesterol (HDLC), apolipoprotein A/B (ApoA/B) ratio seemed as protective factors. After controlling the effect of the other variables, OR of LPL genotype PVUⅡ(--) and haplotype H+P- were 17.18 and 3.67, while OR of HDLC, ApoA/B ratio were respectively 0.14, 0.15 in model A and 0.04, 0.09 in model B. Conclusion These results indicated that LPL genotype PVUII(--) or haplotype H+P- other than the conventional risk factors were contributing in CHD and that HDLC, ApoA/B ratio may be the better independent predictors for CHD than the other plasma lipid parameters.

关 键 词：冠心病 脂蛋白脂酶 基因多态性 

分 类 号：R541.4[医药卫生—心血管疾病]