谷胱甘肽与铜绿假单胞菌致病性的关系  

The Relationship Between Glutathione and the Pathogenicity of Pseudomonas aeruginosa

作　　者：张亚妮[1] 梁海华[1] 段康民[1] 

机构地区：[1]西北大学生命科学学院,陕西西安710069

出　　处：《微生物学通报》2009年第9期1418-1422,共5页Microbiology China

基　　金：国家自然科学基金项目(No.30470098);陕西省教育厅基金项目(No.07JK410);西北大学校内基金项目(No.05NW41)

摘　　要：铜绿假单胞菌由于对抗生素的固有耐药和多重抗药性,已成为医院内感染的重要病原菌之一。谷胱甘肽是细胞内最重要的抗氧化剂,保护细胞免受氧化压力的损害。但是在铜绿假单胞菌感染的组织中,由于绿脓菌素等致病因子的存在,可以导致谷胱甘肽的水平降低。同时,谷胱甘肽又可以增强绿脓菌素的致病性。本文就谷胱甘肽与铜绿假单胞菌关系的最新研究进展并结合作者的工作,对上述问题进行了综述和探讨。Pseudomonas aeruginosa is one of the most common causes of nosocomial infection due to its intrinsic resistance to antibiotics. In the host, glutathione （GSH）, one of the most important intracellular antioxidants, provides protection against high levels of oxidative stress. A decrease in GSH levels in tissues infected with P. aeruginosa has been observed while interactions between pyocyanin and GSH maybe partially attribute to P. aeruginosa infection. In this review, the relationship between GSH and the pathogenicity of P. aeruginosa has been discussed based on the author＇s own research results and the latest literature.

关 键 词：谷胱甘肽 铜绿假单胞菌 氧化压力 绿脓菌素 

分 类 号：R515[医药卫生—内科学]