精子蛋白Ropporin的研究进展  

Advances in the Researches of Spermatogenic Protein,Ropporin

作　　者：陈静[1] 蔡志明[1] 桂耀庭[1] 

机构地区：[1]北京大学深圳医院,广东省暨深圳市男性生殖与遗传重点实验室,广东深圳518036

出　　处：《中华男科学杂志》2009年第9期833-835,共3页National Journal of Andrology

基　　金：国家自然科学基金(30770810);广东省科技计划项目(2007B060401061);深圳市科技计划项目(200602059)~~

摘　　要：Ropporin一直以来被认为是精子细胞特异性蛋白,在睾丸组织中特异性表达,并参与精子的运动、获能、顶体反应等生理活动。然而,新的研究表明Ropporin在正常的非睾丸组织也有微弱表达,而且作为一种新的肿瘤睾丸抗原(CT抗原)在恶性血液病的肿瘤细胞中高表达。Ropporin在哺乳动物中的表达具有高度保守性,说明它对生命的重要性。本文就Ropporin的特性、表达与分布、生理学功能及临床研究的新进展进行了综述。Ropporin has been identified as a spermatogenic cell-specific protein and may be involved in sperm maturation, motility, capacitation, hyperactivation and acrosome reaction. However, latest studies have shown that Ropporin is expressed weakly in normal non-testis tissues and highly in hematologic malignancies. Its highly conservative expression in mammalians demonstrates its importance to life. This paper updates the characterization, expression and its distribution, and biological function of Ropporin, and the advances in the clinical researches of the protein.

关 键 词：精子蛋白 Ropporin 肿瘤睾丸抗原 

分 类 号：R33[医药卫生—人体生理学]