氟比洛芬酯对开胸术后硬膜外镇痛效果的影响  

Effects of Flurbiprofen Axetil on Patient Controlled Epidural Analgesia after Thoracotomy

作　　者：朱志荣[1] 王剑[2] 宁雪[1] 何伟雄[2] 

机构地区：[1]广州医学院附属肿瘤医院麻醉科,广东广州510095 [2]华南肿瘤学国家重点实验室//中山大学肿瘤防治中心麻醉科,广东广州510060

出　　处：《中山大学学报（医学科学版）》2009年第A03期181-184,共4页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：广东省科技计划项目(2007B031500002)

摘　　要：【目的】探讨复合静脉使用氟比洛芬酯于开胸手术术后自控硬膜外镇痛,对镇痛的效果影响。【方法】40例ASAI-Ⅱ择期开胸手术患者,随机分为2组(n=20):硬膜外镇痛组(E组)与硬膜外复合静脉镇痛组(C组)。在手术结束后,两组患者均使用硬膜外连续自控镇痛。复合静脉镇痛组(C组)术后额外予以静脉注射氟比洛芬酯注射液50mg每12h一次。记录术后第12(T1)、24(T2)、36(T3)、48h(T4)疼痛评分(安静时与活动时分别进行评分)以及硬膜外镇痛药消耗量。并同时记录不良反应包括恶心、呕吐、皮肤瘙痒。【结果】术后24h时开始,C组累计镇痛药使用量,在此后各观察时间点均较较P组小(P<0.05);VAS评分C组也较E组低(P<0.05),不良反应包括恶心、呕吐、皮肤瘙痒两组无显著统计学差异。【结论】复合静脉使用氟比洛芬酯50mg每12h一次于术后硬膜外镇痛,可获得更加确切的镇痛效果,并不增加不良反应的发生率。[ Objective] This study was to investigate the effects of flurbiprofen axetil on patient controlled Epidural analgesia （PCEA） after thoracotomy. [Methods] 40 ASAⅠ-Ⅱ patients scheduled for major thoracic surgery were assigned to 2 groups randomly： the epidural analgesia group （Group E） and the combined group （Group C）. Group E was treated as Patient controlled Epidural analgesia （PCEA） after the surgery for 2 days, as to the Group C, based on PCEA, flurbiprofen axetil 50mg Q12h was administration intravenous additionally. VAS scores, side effects including nausea and vomiting , the total analgesic consumption were recorded at the time point of 12 h（T1）,24 h（T2）、36 h（T3）、48 h（T4） after surgery. [Results] VAS score in Group C was lower than Group E significantly （P 〈 0.05） 12 h after surgery, and the consumption of analgesic drugs of Group C were also smaller than that of Group E. [ Conclusions ] Flurbiprofen axetil could improve the analgesia effects and lower the analgesic consumption during PCEA.

关 键 词：氟比洛芬酯 镇痛 剖胸术 

分 类 号：R61[医药卫生—外科学]