开郁清胃颗粒对OLETF大鼠肝脏和骨骼肌细胞膜胰岛素受体结合率的影响  

Effect of Kaiyu-Qingwei-Keli on the Binding Rate of Insulin Receptor of Liver and Skeletal Muscle Cell Membranes in OLETF Rat

作　　者：仝小林[1] 柳红芳[2] 刘红星[3] 

机构地区：[1]中国中医科学院广安门医院,北京100700 [2]北京中医药大学东直门医院,中医内科学教育部重点实验室,北京市普通高校重点实验室 [3]中日友好医院,北京100029

出　　处：《中国中医基础医学杂志》2009年第8期588-590,共3页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：基于代谢组学的腹型肥胖中医虚实辨证研究(30672580);2型糖尿病痰热互结证生物学基础研究(7490709049);吕亚芳基金资助

摘　　要：目的:研究开郁清胃颗粒对OLETF胰岛素抵抗大鼠肝及骨骼肌细胞膜胰岛素受体结合率的影响。方法:32周龄雄性OLETF实验大鼠随机分成4组:模型组、罗格列酮组、开郁清胃颗粒大、小剂量组,正常对照组选用同龄Wastar大鼠。各组分别给药4周行正常血糖高胰岛素钳夹实验后检测各项指标。结果:中药小剂量治疗组与糖尿病模型组相比,肝脏及肌肉细胞膜胰岛素受体结合率升高(P<0.01或P<0.05),胰岛素和胰高血糖素水平无明显变化。结论:开郁清胃颗粒可增加肝及骨骼肌细胞膜胰岛素受体结合率。To investigate the effect of Kaiyu-Qingwei-Keli on insulin binding rate of liver and skeletal muscle cell membranes in OLETF rat. Methods：At age of 32 weeks male OLETF rats were randomly divided into four groups, i. e model group, rosiglitazone group, small and big dose Kaiyu-Qingwei-Keli group. The same age Wastar rats were chosed as the normal group. Various items were measured after 4 weeks treatment and englycemic clamp method. Results： Kaiyu-Qingwei-Keli small dose group had higher rate insulin binding of liver and muscle cell membranes （ P 〈 0.05 or P 〈 0.01）than that of model group （ P 〈 0.001）. But the level of insulin and glucagon had not obvious change. Conclusion：The mechanism of Kaiyu-Qingwei-Keli was that it can increased the binding rate of insulin receptor of liver and muscle cell membranes.

关 键 词：开郁清胃颗粒 胰岛素受体结合率 胰岛素抵抗 

分 类 号：R285.5[医药卫生—中药学]