SARS患者后遗症与HLA-A基因相关性的研究  

A study on association between SARS patients′ sequelae and HLA-A allele

作　　者：何丽 魏茂提[2] 韩燚[2] 张克菊[2] 杨震[2] 王世鑫[2] 

机构地区：[1]武警甘肃总队医院内科,兰州730050 [2]武警医学院蛋白组学实验室

出　　处：《中国预防医学杂志》2009年第9期825-828,共4页Chinese Preventive Medicine

基　　金：天津市科技攻关重点项目(05YFSZSF02900);武警医学院院级项目(WY-2006-16)

摘　　要：目的研究我国汉族SARS康复患者发生肺间质纤维化及股骨头缺血性坏死与HLA-A基因多态性的相关性。方法应用PCR-SBT的研究方法对53例SARS患者HLA-A位点进行基因分型,直接计数法进行基因频数计算,采用卡方检验进行资料比较。结果康复SARS患者中,按照是否发生肺间质纤维化来分,未见HLA-A位点的等位基因频率分布在两组人群间,差异有统计学意义(P>0.05);同时,按照是否发生股骨头缺血性坏死来分,未见HLA-A位点的等位基因频率分布在两组人群间,差异有统计学意义(P>0.05)。结论HLA-A基因可能与SARS患者发生肺间质纤维化及股骨头缺血性坏死无关。Objective To study the association of HLA-A gene polymorphism with SARS patients＇ sequelae in Chinese Han population. Methods Polymerase chain reaction-sequence based typing （PCR-SBT） was used to determine the polymorphism of HLA-A gene in SARS patients. Results There was no significant difference of the distribution of HLA-A allele frequency in SAR5 patients classified by interstitial lung fibrosis or femoral head necrosis （ P 〉 0. 05 ）. Conclusion There might be no relationship between HLA-A gene polymorphism and interstitial lung fibrosis and femoral head necrosis of patients with SARS.

关 键 词：SARS HLA-A基因 肺间质纤维化 股骨头缺血性坏死 

分 类 号：R511.9[医药卫生—内科学]