血清、尿胱抑素C测定对评价早期肾功能损害的意义  

Diagnostic Value of Serum and Urine Cystatin C Detection for Early Renal Function Impairment

作　　者：杨彩云[1] 沈颖[1] 林影[1] 

机构地区：[1]首都医科大学附属北京儿童医院内科,北京100045

出　　处：《实用儿科临床杂志》2009年第17期1366-1368,1377,共4页Journal of Applied Clinical Pediatrics

摘　　要：长期以来血清尿素氮(BUN)、肌酐(Scr)及肌酐清除率(Ccr)等的测定是临床最常用的评价肾功能的指标,但易受肾外因素的影响,敏感性不佳,不能准确及时的反映肾功能。近十余年,胱抑素C(Cys C)作为新近发展起来的一个评价肾功能早期损害的灵敏标记物倍受关注。研究表明,血清Cys C(sCys C)对肾小球滤过率(GFR)的评价有较好的敏感性及准确性,测定sCys C水平对监测GFR的变化有重要意义。但sCys C能否作为Scr的替代标记物,还有待进一步论证。由于Scr存在难以克服的缺点,联合sCys C和Scr检测对临床肾功能监测有重要价值。As we known, serum creatinine（Scr）, serum urea nitrogen（SUN） and creatinine clearance rate （Ccr）, the most established marker of renal function, are affected by age, gender, muscle mass or nutritional status. Scr determines the glomerular filtration rate （GFR） improperly. Serum Cystatin C （sCys C ） is freely filtered at the glomerulus and then resorbed and fully catabolised by proximal renal tubules, making it an ideal marker of GFR. It is not affected by gender,muscle mass or malignancy,its production rate is usually constant and its plasma concentration therefore is dependent only on GFR. sCys C has been demonstrated to be more accurate and sensitive than Set in the detection of early renal impairment and in specific populations may allow for early detection of renal disease. The aim is to discuss the advantages and limitations of sCys C and of established GFR methods.

关 键 词：生物学标记 胱抑素C 肾功能 

分 类 号：R446.6[医药卫生—诊断学]