维生素E微囊兔体内药代动力学参数测定  

Pharmacokineties of Vitamin E microcapsules in rabbits

作　　者：冯琳[1] 傅军鹏 王波 王景祥[1] 

机构地区：[1]济南军区总医院药理科,济南250031

出　　处：《药学实践杂志》1998年第4期193-195,共3页Journal of Pharmaceutical Practice

摘　　要：目的：测定维生素Ｅ微囊在健康家兔体内的药物动力学参数。方法：６只健康家兔随机交叉灌胃服用维生素Ｅ微囊，并用紫外分光光度法测定血浆中的血药浓度。结果：经ＰＫＰＢ－Ｎ１程序包拟合，药－时曲线符合一级吸收的双室模型。动物服用维生素Ｅ微囊后，血浆中药物Ｔ_（１／２Ｋａ）＝３．２４６±１．６６７ｈ，Ｔ_（１／２ａ）＝７．１５０±１．８９９ｈ，Ｔ_（１／２β）＝３８．３０５±３．３４ｈ，达峰时间是１２．１０±３．８０７ｈ，达峰浓度是８．６５２±２．４０４ｍｇ／Ｌ，曲线下面积为２６４．５６±９０．６９．ｍｇ／Ｌ．The pharmacokineties of vitamine E microcapsules were studied. Concentration of plasma was determined by UV after ig 100mg/kg Vitamin E of vitamin E microcapsules being given rabbits.The pharmacokineties of vitamin E fitted to a two - compartment medal with lag time using PKBP - N1 program. The results of vitamin E microcapsules is: t_(1/2)Ka = 3. 246 ± 1. 667h, t_(1/2－)α = 7. 150 ± 1. 899, t_(1/2)β = 38.305 ± 13.34h, C_(max) = 8.625 ± 2.404mg/L;T_(max) = 12. 10 ± 3.807;AUC_(0-∞) = 298.36 ± 80.20h mb/L.

关 键 词：维生素E 微囊 药物代谢动力学 家兔 

分 类 号：R977.25[医药卫生—药品] R969.1[医药卫生—药学]