糖尿病性视网膜病变视网膜电图振荡电位的频域和时域分析  

Analysis of oscillatory potentials of electroretinogram in frequency domain andtime domain in diabetic retinopathy eyes

作　　者：梁小玲[1,2] 余敏忠[1,2] 文峰[1,2] 吴德正[1,2] 罗苔青[1,2] 

机构地区：[1]卫生部眼科学实验室 [2]中山医科大学中山眼科中心

出　　处：《中国实用眼科杂志》1998年第8期458-461,共4页Chinese Journal of Practical Ophthalmology

摘　　要：为分析早期和晚期ＤＲ患者ＥＲＧ的ＯＰｓ频域和时域参数，为ＤＲ的早期诊断和估计预后提供客观指标。测定和比较了１７只Ⅰ～Ⅱ期ＤＲ患眼、４５只Ⅳ～Ⅴ期ＤＲ患眼和４０只正常对照眼的ＯＰｓ频域和时域参数。结果：Ⅰ～Ⅱ期和Ⅳ～Ⅴ期ＤＲ患眼与正常对照眼比较，部分平均频谱的幅度、总功率、最大振幅和最大功率均有显著下降；ＯＰｓ四个子波的潜伏期均显著延长，振幅均显著下降，四个子波振幅总和显著下降；主频率只在Ⅳ～Ⅴ期组显著下降。Ⅳ～Ⅴ期与Ⅰ～Ⅱ期ＤＲ患眼比较，部分平均频谱的幅度、最大振幅和最大功率有显著下降；ＯＰｓ前两个子波的潜伏期有显著延长，四个子波振幅及其振幅总和均有显著下降。结论：ＯＰｓ的频域和时域参数可作为评价ＤＲ不同病程和估计预后的客观指标。National　Ophthalmological　Laboratories,Ministry　of　Public　Health;Zhongshan　Ophthalmic　Centre,Sun　Yatsen　University　of　Medical　Sciences,Guangzhou　510060,P　R　ChinaPurpose:To　analyze　the　OPs　parameters　frequency　domain　and　time　domain　in　early　and　late　DR　and　provide　reference　for　the　clinical　research,diagnosis　and　prognosis　of　DR.Methods:The　OPs　parameters　in　frequency　domain　and　time　domain　from　17　eyes　of　Ⅰ～Ⅱ　phase　DR,45　eyes　of　Ⅳ～Ⅴphase　DR　and　40　normal　control　eyes　were　tested　and　compared　between　groups.Results:Comparing　with　the　normal　control　group,a　part　of　magnitudes　of　the　mean　frequency　spectra,the　total　power,the　maximum　magnitude,the　maximum　power　were　significantly　decreased,the　latencies　of　the　four　wavelets　of　OPs　prolonged　significantly,the　amplitudes　and　the　sum　of　the　four　wavelets　were　decreased　significantly　in　both　Ⅰ～Ⅱ　phase　DR　and　Ⅳ～Ⅴ　phase　DR;the　dominant　frequency　was　significantly　decreased　only　in　Ⅳ～Ⅴ　phase　DR.Comparing　with　Ⅰ～Ⅱ　phase　DR,a　part　of　magnitudes　of　the　mean　frequency　spectra,the　maximum　magnitude,the　maximum　power　were　significantly　decreased,the　latencies　of　the　earlier　two　wavelets　of　OPs　prolonged　significantly,the　amplitudes　and　the　sum　of　the　four　wavelets　were　decreased　significantly　in　Ⅳ～Ⅴ　phase　DR.Conclusion:OPs　may　be　used　as　objective　index　in　evaluation　of　DR　with　different　extent　and　in　prognosis　of　DR.

关 键 词：视网膜病变 糖尿病 视网膜电流图 振荡电位 

分 类 号：R587.2[医药卫生—内分泌] R774.120.4[医药卫生—内科学]