Chibby在拮抗Wnt／β-catenin信号通路中的研究进展  

Advances in Chibby＇ s inhibition in the Wnt/β-catenin singaling pathway

作　　者：杜红梅(综述)[1] 徐洪涛(审校)[1] 

机构地区：[1]中国医科大学基础医学院病理学教研室,沈阳110001

出　　处：《国际肿瘤学杂志》2009年第9期643-646,共4页Journal of International Oncology

基　　金：国家自然科学基金资助项目（30801135）

摘　　要：经典Wnt／β-catenin信号通路在许多肿瘤的发生过程中扮演重要角色，而最近研究发现，一种在进化中高度保守的核蛋白Chibby，可通过两条不同的途径来拮抗经典Wnt／β-catenin信号通路，从而对Wnt／β-catenin信号通路异常激活的肿瘤有一定程度的抑制作用，给研究肿瘤提供了新的视角。It is well known that canonical Wnt/β-catenin signaling pathway plays a key role in tumorigenesis. Recent studies show that Chibby as an antagonist of the Wnt/β-catenin signaling pathway is a kind of nuclear protein that has been conserved throughout evolution. Chibby inhibits Wnt/13-catenin pathway at least through two distinct molecular pathways. Thus Chibby could inhibit the progression of tumors whose Wnt/β- catenin pathway is abnormally activated. This provids a new perspective in tumor research.

关 键 词：肿瘤 Chibby 信号传导 

分 类 号：R282.71[医药卫生—中药学] R542.2[医药卫生—中医学]