镁对实验性动脉粥样硬化家兔机体抗氧化体系机能的影响  

Magnesium on Functional Effects of Body Antioxidant system in Experimental Atherosclerotic rabbits

作　　者：李兴琴[1] 王素敏[1] 刘福英[1] 张杰[1] 孙新新 

机构地区：[1]河北省医学科学院

出　　处：《微量元素与健康研究》1998年第3期10-11,共2页Studies of Trace Elements and Health

基　　金：河北省科委资助

摘　　要：用高脂膳食诱导的动脉粥样硬化家兔心肌组织和肝脏抗氧化体系机能的改变规律及镁对机体抗氧化机能的影响。提示：动脉粥样硬化家兔心脏超氧化歧化酶（ＳＯＤ）及ＳＯＤ／ＬＰＯ比值显著降低，而过氧化脂质（ＬＰＯ）明显升高。肝组织ＬＰＯ含量升高显著，而谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）、ＳＯＤ活性及ＳＯＤ／ＬＰＯ和ＧＳＨ－Ｐｘ／ＬＰＯ显著降低。补充镁显著降低心脏ＬＰＯ含量，并使肝脏的ＳＯＤ、ＧＳＨ－Ｐｘ及ＳＯＤ／ＬＰＯ、ＧＳＨ－Ｐｘ／ＬＰＯ与心脏ＳＯＤ／ＬＰＯ比值明显升高。提示：动脉粥样硬化家兔机体抗氧化机能明显减低，这种变化可能在动脉粥样硬化的发生、发展中起重要作用。而镁对机体抗氧化机能产生一定的影响。Functional effects of body of antioxidant system and the preventive effects of magnesium were examind in hight-fat-induced New Zealand white rabbits.The results showd that,activities of superoxide dismutase(SOD)and SOD/LPO in heart of atherosclerotic rabbits were significantly lower than that of the control,the lipid peroxide (LPO)levels of atherosclerotic heart were markedly higher than that of the control and atherosclerotic rabbits were associated with decreased liver GSHPx、SOD or SOD/LPO and GSHPx/LPO significantly,meanwhile liver SOD、GSHPx or SOD/LPO and GSHPx/LPO and heart SOD/LPO were reduced.there findings suggested that the body antioxidant function in atherosclerotic rabbits was decreased obviously and this change might play an important role in the development of atherosclerotic magnesium is benefical in preveting atherosclerotic.

关 键 词：镁 动脉粥样硬化 抗氧化作用 家兔 

分 类 号：R543.5[医药卫生—心血管疾病] Q582[医药卫生—内科学]