离子对萃取光度法测定复方安乃近微型灌肠剂中盐酸氯丙嗪含量  

Determination of chlorpromazine hydrochloride in microenema analginum compositum by ion pair extraction spectrophotometry

作　　者：王章阳[1,2] 王亮明[1,2] 孟晓红[1,2] 钟新华 范华荣 

机构地区：[1]华西医科大学药学院 [2]中科院成都分院

出　　处：《中国医院药学杂志》1998年第9期404-406,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的：解决高浓度安乃近共存情况下，盐酸氯丙嗪的含量测定。方法：以溴麝香草酚蓝为反离子，甲苯为萃取溶剂，建立了复方安乃近微型灌肠剂中盐酸氯丙嗪的含量测定方法。结果：测定波长４０４±１ｎｍ，线性范围２０～１４０μｇ·ｍｌ－１。平均方法回收率１００．４％，ＲＳＤ＝１．６％。结论：基质及高浓度安乃近不干扰测定。由摩尔比法测得溴麝香草酚蓝与盐酸氯丙嗪缔合比为２∶１。OBJECTIVES: To determine the content of chlorpromazine hydrochloride in the samples with high concentration of analginum. METHODS: The extraction spectrophotometry with bromothymol blue as counter ion had been established for the measurement of chlorpromazine hydrochloride. RESULTS: The absorbance at 404nm showed the linear relationship in range of 20-140 μg/ml, with mean recovery of 100.4% , RSD of 1.55% ( n =9). CONCLUSIONS: Both blank and analginum showed no interference. The molecule rate of bromothymol blue to chlorpromazine hydrochloride was 2∶1.

关 键 词：盐酸氯丙嗪 复方安乃近 灌肠剂 比色法 

分 类 号：R971.1[医药卫生—药品] R927.2[医药卫生—药学]