2型糖尿病患者血清1,25-二羟基维生素D_3的变化及意义  

The variance and significance of blood serum 1,25-dihydroxyvitamin D_3 in type2 diabetes mellitus patients

作　　者：邵雪景[1] 蒋秀琴[1] 李慧敏[1] 缪珩[1] 

机构地区：[1]南京医科大学第二附属医院内分泌科,江苏南京210011

出　　处：《南京医科大学学报（自然科学版）》2009年第10期1417-1419,1443,共4页Journal of Nanjing Medical University(Natural Sciences)

基　　金：江苏省卫生厅医学科技发展基金课题(H200609)

摘　　要：目的:比较2型糖尿病患者与正常人之间血清1,25-二羟基维生素D3[1,25(OH)2D3]水平的差异,分析维生素D与2型糖尿病的关系。方法:选择2型糖尿病患者110例为病例组,同期本院健康体检者105例为对照组。用ELISA法测定血清1,25(OH)2D3水平,同时进行问卷调查并检测相关临床及生化指标,统计分析。结果:血清1,25(OH)2D3在病例组和对照组中的差异明显(P<0.01),血清1,25(OH)2D3与空腹血糖呈显著负相关(rs=-0.696,P<0.01)。结论:血清1,25(OH)2D3在2型糖尿患者中明显低于正常人。空腹血糖越高,血清1,25(OH)2D3越低。Objective：To compare the difference of serum 1,25-dihydroxyvitamin D3（1,25（OH）2D3） between type 2 diabetes mellitus patients and normal persons,and to analyze the relationship between vitamin D3 and type 2 diabetes mellitus. Methods： 110 patients with type 2 diabetes mellitus were selected as the case group,and 105 healthy people were selected as the control group. ELISA was used for the detection of serum 1,25-dihydroxyvitamin D3. Questionnaire survey was performed,and clinical and biochemical indexes were also detected. Results：There was a significant difference in serum 1,25 （OH）2D3 level between the case and control group （P 〈 0.01 ）. There was a significant negative correlation between serum 1,25 （OH）2D3 level and fasting blood glucose （rs=-0.696, P 〈 0.01 ）. Conclusion：Serum 1,25 （OH）2D3 in the case group was significantly lower than that in the control group. The higher fasting blood glucose, the lower serum 1,25 （OH） 2D3.

关 键 词：2型糖尿病 1 25-二羟基维生素D3 空腹血糖 

分 类 号：R587.1[医药卫生—内分泌]