前列安通片对精索静脉曲张大鼠附睾α-糖苷酶、L-肉毒碱的影响  

Effect of Qianlieantong tablets on α-glucosidase and L-carnitine in epididymis in rats with varicocele

作　　者：尹静[1] 曲晓伟[1] 郭凯[2] 张培海[2] 张蜀武[2] 

机构地区：[1]成都中医药大学,四川成都610075 [2]成都中医药大学附属医院,四川成都610075

出　　处：《现代中西医结合杂志》2009年第28期3416-3418,共3页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的观察α-糖苷酶、L-肉毒碱在精索静脉曲张大鼠附睾的表达情况,探讨前列安通片提高生育力可能的作用机制。方法将SD大鼠通过缩窄左肾静脉制备精索静脉曲张大鼠模型,随机分为假手术组、模型组、前列安通片组、桃红四物汤组。连续药物干预4周后,观察精子密度、活力,检测附睾α-糖苷酶、L-肉毒碱的含量。结果模型组大鼠精子活力与密度低下,附睾α-糖苷酶、L-肉毒碱呈弱表达;前列安通片组、桃红四物汤组大鼠精子活力与密度明显增高,前列安通片组较桃红四物汤组增高明显(P均<0.05)。结论前列安通片可提高精索静脉曲张大鼠精子密度和活力,提高附睾α-糖苷酶、L-肉毒碱含量,并可能通过此作用而达到提高生育力的目的。Objective It is to observe the expression of α- glucosidase, L- carnitine in epididymis in rats with varicocele, and to explore the mechanism of Qianlieantong tablets for improving fertility. Methods SD rats were made into models of varieocele by narrowing the left renal vein, then they were randomly divided into sham operation group, model group, Qianlieantong tablets group, Taohong Siwutang group. After drug intervention for 4 weeks, sperm density, vitality was observed and the contents of epididymal α - glucosidase, L - carnitine were determined. Results The density and vitality of sperm were low and the expression of epididymal α - glucosidase and L - carnitine were weak in model group. The density and vitality of sperm in Qianlieantong tablets group and Taohong Siwutang group both increased obviously, and the increase was more significant in the former group than that in the latter group （ P 〈 0.05）. Conclusion Qianlieantong tablets can improve sperm density and vitality of rats with varicocele, improve the content of Epididymal α- glucosidase and L- carnitine content. We maybe reach the purposes of improving fertility through this role.

关 键 词：前列安通片 精索静脉曲张 不育 Α-糖苷酶 L-肉毒碱 

分 类 号：R697.24[医药卫生—泌尿科学] R277.573.3[医药卫生—外科学]