西洛他唑抗缓慢性心律失常的实验研究  

Anti-bradyarrhythmia Efficacy of Cilostazol:An Experimental Study

作　　者：王兴满[1] 董六一[1] 高署 

机构地区：[1]安徽医科大学,合肥市230032 [2]合肥合源医药有限责任公司,合肥市230084

出　　处：《中国药房》2009年第28期2189-2191,共3页China Pharmacy

摘　　要：目的:研究西洛他唑抗实验性缓慢性心律失常的作用及机制。方法:采用盐酸维拉帕米与烟碱诱发小鼠缓慢性心律失常模型,记录不同时间段心电变化,观察灌胃给予西洛他唑不同剂量后对小鼠心率的影响;采用家兔在体希氏束电图的方法,检测家兔灌胃给予西洛他唑不同剂量后在体希氏束电图A-H间期及H-V间期,并与生理盐水对照组比较。结果:盐酸维拉帕米与烟碱可显著减慢小鼠的心率,而西洛他唑可显著加快各治疗组小鼠的心率(P<0.01);家兔在体希氏束电图上,西洛他唑各剂量组A-H间期与生理盐水对照组比较均明显缩短(P<0.01),而H-V间期变化不明显。结论:西洛他唑具有明显的抗缓慢性心律失常的作用,其作用与提高窦房结自律性及加快传导有关。OBJECTIVE： To study the effect and mechanism of cilostazol in experimental anti- bradyarrhythmia. METHODS： Bradyarrhythmia model of mice was induced using verapamil hydrochloride and nicotine, respectively. The electrocardiograms at different time and the heart rates of the model mice after intragastric administration of different dosages of cilostazol were recorded. The in vivo His＇ bundle electrogram （HBE） recordings in rabbits were obtained after intragastric administration of different dosage of eilostazol for detection of A-H interval and H- V interval, which were compared with control group （normal saline group）. RESULTS： Verapamil hydrochloride and nicotine markedly slowed down the heart rates of mice, but cilostazol significantly sped up the heart rates in mice （P〈0.01） . The in vivo HBE showed markedly shortened that A- H interval in rabbits after treatment with different dosages of cilostazol （P〈0.01） as compared with the control group, however, the difference in H- V interval was nonsignificant. CONCLUSION： The remarkable antibradyarrhythmia efficacy of Cilostazol might be achieved by enhancing the autorhythmicity of atrionector and speeding up the electrical conduction speed between atrium and ventricle.

关 键 词：西洛他唑 缓慢性心律失常 小鼠 盐酸维拉帕米 烟碱 家兔 希氏束电图 

分 类 号：R965[医药卫生—药理学] R973[医药卫生—药学]