陵水暗罗枝、叶中的阿朴菲生物碱  

Aporphine alkaloids from branches and leaves of Polyalthia nemoralis

作　　者：吕子明[1] 张庆建[1] 陈若芸[1] 于德泉[1] 

机构地区：[1]中国医学科学院北京协和医学院药物研究所中草药物质基础与资源利用教育部重点实验室,北京100050

出　　处：《中国中药杂志》2009年第18期2343-2348,共6页China Journal of Chinese Materia Medica

摘　　要：目的：对陵水暗罗Polyalthia nemoralis枝、叶中的阿朴菲生物碱进行分离和鉴定，并测细胞毒活性。方法：采用硅胶和凝胶柱色谱方法进行分离纯化，利用波谱数据和理化常数鉴定化合物的结构；MrlT法测试细胞毒活性。结果：从乙醇提取物中分离鉴定了5个阿朴菲生物碱，分别为bidebilineA（1），annobraine（2），lanuginosine（3），鹅掌楸碱（1iriodenine，4），oxostephanosine（5）。结论：化合物2，5为首次从该属中分到，1，3，4为首次从该植物中分离得到；化合物3—5对多种癌细胞生长有抑制作用。Objective： To study the caffeoylquinic acid derivatives from the leaves of Lonicera japonica. Method： The compounds were isolated by column chromatography and identified on the basis of physico-chemical constants and spectral analysis. Result： Five caffeoylquinic acid derivatives were isolated,and their structures were identified as 3,4-di-O-caffeoyl quinic acid methyl ester （1） , 5-O-caffeoyl quinic acid methyl ester （2） , 3,4-di-O-caffeoyl quinic acid （3）, 1,3-di-O-caffeoyl quinic acid （4） and chlorogenic acid （5）, respectively. Conclusion： Compounds 2, 4 were obtained from this genus for the first time. Compounds 1, 3 were obtained from this plant for the first time.

关 键 词：陵水暗罗 阿朴菲生物碱 结构鉴定 细胞毒 

分 类 号：R284.1[医药卫生—中药学] R914.5[医药卫生—中医学]