新型含肟醚Strobilurins衍生物的合成及杀菌活性研究  

Synthesis and Fungicidal Activities of Novel Oxime Ether Strobilurins

作　　者：柳爱平[1,2] 何海军[1,2] 刘兴平[1] 何莲[1] 胡春华[1,3] 魏振中[1,3] 胡志彬[1] 黄明智[1] 欧晓明[1] 苏胜培[2] 

机构地区：[1]湖南化工研究院国家农药创制工程技术研究中心,长沙410007 [2]湖南师范大学化学生物学及中药分析教育部重点实验室,长沙410081 [3]华中师范大学化学学院,武汉430079

出　　处：《有机化学》2009年第9期1381-1386,共6页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.20572019;20872033);湖南省自然科学基金(Nos.06JJ2054;09JJ3015);湖南省杰出青年基金(No.07JJ1003);国家"十一五"(No.2006BAE301A01-4)资助项目

摘　　要：Strobilurins类化合物具有优异的杀菌活性,设计并合成了12个未见文献报道的含肟醚Strobilurins类衍生物,其化学结构经1HNMR,IR,HPLC/MS和元素分析表征.初步生物活性测定结果表明,该类化合物具有良好的杀菌活性,如6b～6d和6h在500μg/mL浓度下对小麦白粉病菌的防效达90%以上,同时,6c和6d对稻瘟病菌的抑制率也达90%以上,其中,化合物6c在25μg/mL的浓度下,对小麦白粉病菌的防效仍达72%.Strobilurin derivatives have significant fungicidal activity, hence, twelve new strobilurin derivatives containing oxime ether moiety were designed and synthesized, and their structures were confirmed by 1H NMR, IR, HPLC/MS techniques and elemental analysis. Preliminary bioassay showed that most of these title compounds had potent fungicidal activity. For example, 6b-6d and 6h exhibited more than 90% activities against Blumeria graminis at a concentration of 500 μg/mL. Furthermore, compounds 6c and 6d also showed more than 90% inhibition against Pyricularia oryzae. Especially, compound 6c gave 72% control against Blumeria graminis at 25μg/mL.

关 键 词：STROBILURINS 杀菌活性 合成 构效关系 

分 类 号：TQ455.4[化学工程—农药化工]