1,5-二取代吡唑基-1,4-戊二烯-3-酮类化合物的合成及生物活性研究  

Synthesis and Biological Activity of 1,5-Bis(substituted pyrazol-4-yl)-1,4-pentadien-3-one Derivatives

作　　者：王振宁[1] 胡德禹[1] 宋宝安[1] 杨松[1] 金林红[1] 薛伟[1] 

机构地区：[1]贵州大学精细化工研究开发中心教育部绿色农药与农业生物工程重点实验室,贵阳550025

出　　处：《有机化学》2009年第9期1412-1418,共7页Chinese Journal of Organic Chemistry

基　　金：国家科技部国际重大合作(No.2005DFA30650);国家自然科学基金(No.20662004);贵州省省长基金(No.200624)资助项目

摘　　要：设计合成了13个未见文献报道的1,5-二取代吡唑基-1,4-戊二烯-3-酮类化合物,其结构经元素分析,1HNMR,IR确证.初步生物活性测试结果表明,部分化合物有一定的抗烟草花叶病毒(TMV)活性,所有化合物抑菌活性较低.In order to find novel anti-TMV and antifungal compounds with high activity and low toxicity, thirteen new 1,5-bis（substituted pyrazol-4-yl）-1,4-pentadien-3-one derivatives were synthesized. Their structures were characterized by IR, ^1H NMR spectra and elemental analysis. Preliminary bioassays indicated that some compounds showed moderate activity against TMV, and all compounds showed weak antifungal activity.

关 键 词：1 4-戊二烯-3-酮类衍生物 吡唑 合成 生物活性 

分 类 号：TQ450.21[化学工程—农药化工]