浊度法测定麦迪霉素片剂的效价  

Determination of the Potency of Midecamycin Tablets by Turbidimetric Method

作　　者：高燕霞[1] 姜建国[1] 王茉莉[1] 

机构地区：[1]河北省药品检验所,石家庄050011

出　　处：《中国药师》2009年第10期1372-1374,共3页China Pharmacist

基　　金：2006年河北省科技厅课题(编号:06276445)

摘　　要：目的:建立浊度法测定麦迪霉素片剂含量的方法。方法:以金黄色葡萄球菌为试验菌,加菌量为1.2%～2.5%(V/V),(37±0.5)℃培养4～5h左右测定。结果:麦迪霉素线性浓度为1.0～3.0 IU·ml^(-1),r=0.991 0,平均回收率为102.1%,RSD为2.1%(n=9)。结论:本方法灵敏,快速,影响因素较少,可作为测定麦迪霉素片剂效价的方法。Objective： To establish a turbidimetric method for determination the content of Midecamycin tablets. Method： The test organism was Staphylococcus aureus , adjusted spore suspension of Staphylococcus aureus inoculating with a 1.2% -2.5 % （V/V）ratio, cultivated at（37 ± 0.5 ）℃ for about 4 -5h. Result： The liner range of midecamycin was 1.0 -3.0 IU-ml^-1 （r = 0.991 0）. The average recovery of Midecamycin tablets was 102.1% （ RSD = 2.1%, n = 9）. Conclusion ： The method is sensitive , rapid and feasible to determine the potency of Midecamycin tablets.

关 键 词：效价 浊度法 麦迪霉素 麦迪霉素片 

分 类 号：R927.11[医药卫生—药学]