氨茶碱与注射用甲泼尼龙琥珀酸钠的配伍稳定性考察  

Stability of Aminophylline Injection and Methylprednisolone Sodium Succinate for Injection in Compatibility Solutions

作　　者：徐帆[1] 冯恩富[1] 李锐[2] 梁晓方[3] 苏莉[4] 

机构地区：[1]成都军区昆明总医院,昆明650032 [2]贵阳医学院 [3]遵义医学院 [4]桂林医学院

出　　处：《中国药师》2009年第10期1400-1402,共3页China Pharmacist

摘　　要：目的:考察氨茶碱注射液与注射用甲泼尼龙琥珀酸钠的配伍稳定性。方法:观察及测定2种注射剂在0.9%氯化钠注射液和5%葡萄糖注射液中配伍后于室温放置8h内的外观、pH及不溶性微粒,并采用高效液相色谱法测定配伍液中主药的含量。结果:室温8h内,氨茶碱与甲泼尼龙琥珀酸钠在0.9%氯化钠注射液和5%葡萄糖注射液中的外观、pH均无明显变化,但配伍液的微粒数不断减少,甲泼尼龙琥珀酸钠的含量变化明显。结论:氨茶碱与甲泼尼龙琥珀酸钠不宜在0.9%氯化钠注射液和5%葡萄糖注射液中配伍。Objective： To study the compatible stability of aminophylline injection and methylprednisolone sodium succinate for injection. Method： The changes in appearance, particles and pH of the mixture of the two injections in 0.9% sodium chloride injection and 5% glucose injection within 8 hours at ambient temperature were observed. The concentrations of the mixture of the two injections in 0.9% sodium chloride injection and 5% glucose injection were determined by HPLC within 8 hours. Result： Within 8 hours at room temperature,no obvious changes in appearance and pH were discovered; but particle number and contents of both drugs in 0.9% sodium chloride injection and 5% glucose injection were obviously changed. Conclusion： Aminophylline injection is not shown to be compatible with methylprednisolone sodium succinate for injection in 0.9% sodium chloride injection and 5% glucose injection.

关 键 词：氨茶碱 甲泼尼龙琥珀酸钠 配伍 稳定性 高效液相色谱法 

分 类 号：R942[医药卫生—药剂学]