高压氧治疗对兔腰椎横突间融合的影响  

Effect of hyperbaric oxygen therapy on lumbar intertransverse fusion in rabbits

作　　者：吴建煌[1] 周江南[2] 廖前德[2] 

机构地区：[1]中南大学湘雅医院脊柱外科,长沙410008 [2]中南大学湘雅医院骨科,长沙410008

出　　处：《中南大学学报（医学版）》2009年第7期663-666,共4页Journal of Central South University ：Medical Science

摘　　要：目的:观察高压氧治疗对兔腰椎横突间融合的影响。方法:取28只健康成年雌性白兔,行双侧腰5～6横突间融合。随机分为高压氧治疗组和对照组。术后6周处死动物取腰段脊柱行手术检查、X线摄片、骨密度测定和组织学检查。结果:手术检查结果和X线摄片分析结果显示高压氧治疗组融合率显著高于对照组(P<0.05)。骨密度测定结果显示高压氧治疗组骨密度值显著高于对照组(P<0.05)。组织学观察显示高压氧治疗组的新生骨较对照组多和成熟。结论:高压氧治疗能提高兔腰椎横突间融合的融合率。Objective To observe intertransverse fusion in rabbits. Methods the effect of hyperbaric oxygen （HBO） therapy on lumbar Twenty-eight healthy adult female rabbits underwent lumbar intertransverse fusion at L5-6 with autogenous iliac bone graft. They were randomly assigned into an HBO group and a control group （n = 14 ）. Rabbits were killed 6 weeks after the operation for surgical inspection, X-ray, bone density measurement and histologic analysis. Results The fusion rate of the HBO group evaluated by surgical inspection, and radiologic examination in a blind fashion significantly increased compared with that of the control group （ P 〈 0.05 ）. Qualitative histologic assessment showed increased bone formation and bone maturity in the HBO group compared with the control group. Conclusion Hyperbaric oxygen therapy could improve the fusion rate of lumbar intertransverse fusion in rabbits.

关 键 词：高压氧治疗 腰椎横突间融合 骨密度测定 组织学变化 兔 

分 类 号：R459.6[医药卫生—治疗学] R681.5[医药卫生—临床医学]