异丙酚对大鼠肺缺血／再灌注损伤的保护作用  

The protective effect of propofol on pulmonary ischemia/reperfusion injury

作　　者：李锁北[1] 阮激[1] 徐军美 李艳[2] 吕志平[1] 

机构地区：[1]中南大学湘雅二医院麻醉科,湖南长沙410011 [2]海南省人民医院麻醉科

出　　处：《中国医师杂志》2009年第9期1186-1188,共3页Journal of Chinese Physician

摘　　要：目的研究异丙酚对肺缺血／再灌注损伤的保护作用。方法复制肺缺血再灌注损伤大鼠模型。将成年Wistar大鼠随机分为3组，A组为假手术组；B组为肺缺血一再灌注组，C组为畀丙酚组，每组15只。用酶联免疫吸附（ELISA）法检测支气管肺泡灌洗液（BALF）中TNF-α、IL-6的含量。同时对各纽动物血气和肺湿／干重比（W／D）进行检测。结果异丙酚能明显改善缺血再灌注动物的血氧分压，减少肺W／D值，降低BALF中TNF-α、IL-6含量。结论异丙酚抑制肺缺血再灌注时炎性细胞因子的表达，从而减轻细胞因子介导的炎性损伤，具有肺保护作用。Objective To study the protective effects of propofol against ischemia/reperfusion injury in rat lung. Methods Rat model of pulmonary ischemia/reperfusion injury was used in this study. Rats were randomly divided into three groups, including sham operation group （group A）, ischemia/reperfusion group （group B） and propofol group （group C）, 15 rats in each group. The concentration of tumor necrosis factor -α and interleukin-6 in bronchoalveolar lavage fluid （BALF） were measured by enzyme linked immunosorbent assay （ELISA）. Then blood gas analysis, lung wet/dry （W/D） weight ratiowere detected in each group. Results Propofol could significantly improve PaO2 , reduce the W/D value and the contents of TNF-α and IL-6 in BALF. Conclusion Propofol effectively suppressed the production and release of inflammatory cytokine, therefore it can protect the lung from ischemia/reperfusion injury.

关 键 词：二异丙酚/药理学 肺/血液供给/病理生理学/药物作用 缺血/预防和控制 再灌注损伤/预防和控制 

分 类 号：R614[医药卫生—麻醉学]