三种指标的检测对冠心病诊断的意义  

Significance of lpoprotein(a),hgh-sensitivity C-reative potei,low density ipoprotein-cholesterol in coronary heart disease

作　　者：仝书云[1] 

机构地区：[1]河南省鹤壁煤业集团公司总医院,458000

出　　处：《中国医学创新》2009年第27期126-127,共2页Medical Innovation of China

摘　　要：目的探讨脂蛋白(a)、高敏C反应蛋白(hs-CRP)和低密度脂蛋白胆固醇(LDL-C)检测对冠心病诊断的意义。方法采用免疫比浊法检测LP(a)、酶联免疫吸附法检测125例CHD患者的hs-CRP,常规生化分析仪测定LDL-C。CHD患者中急性心肌梗死(AMI)41例,不稳定型心绞痛(UAP)42例,稳定型心绞痛(SAP)42例,35例健康体检者作为对照组。结果 (1)CHD血清LP(a)、LDL-C、hs-CRP浓度显著高于正常对照组(P<0.01);(2)急性心肌梗死的患者和不稳定型心绞痛患者LDL-C、hs-CRP水平较稳定型心绞痛组升高(P<0.01)。结论 LP(a)、hs-CRP和LDL-C参与CHD的发病过程,三者联合检测有助于了解CHD患者的病情变化和判断预后。Objective To investigate the significance of lipoprotein （ a）, serum level of low density lipoprotein - cholesterol, high -sensitivity c -reactive protein in coronary- heart disease. Methods The level of lipoprotein（a） was detected by turbidimetric immunoassay, hs -CRP were detected by methods of enzyme -linked immunosorbent assay（ ELISA,the level of LDL - C was examined using usual method. Results The patients with CHD had higher level of serum lipoprotein（ a）, hs - CRp and LDL - C than those of control group（ P 〈0. 01 ） ,The serum levels of lipoprotein（a） , hs - CRP and LDL - C in patients with AMI and UAP were higher than that of patients with SAP （ P 〈 0.01 ）. Conclusion LP （a） ,hs - CRP and LDL - C might participate in the occurrence of CHD. Combined detection of lipoprotein（ a）, hs - CRP and LDL - C is helpful to investigate the change of condition and judge the prognosis of patients with coronary heart disease.

关 键 词：冠心病 脂蛋白(a) 低密度脂蛋白胆固醇 高敏C反应蛋白 

分 类 号：R541.4[医药卫生—心血管疾病]