抗Jo-1抗体与皮肌炎和多发性肌炎临床关系的探讨  

Relationship between anti-Jo-1 antibody and polymyositis(PM)/dermatomyositis(DM)

作　　者：张佩莲[1] 李晓岚[1] 邓丹琪[1] 周晓鸿[1] 谢红[1] 付萍[1] 郭芸[1] 王晓云[1] 姜福琼[1] 冒长峙[1] 

机构地区：[1]昆明医学院第二附属医院皮肤性病/风湿免疫科,云南昆明650101

出　　处：《皮肤病与性病》2009年第3期3-5,共3页Dermatology and Venereology

摘　　要：目的探讨抗Jo-1抗体与皮肌炎和多发性肌炎(PM/DM)的临床关系。方法分析16例抗Jo-1抗体阳性的多发性肌炎/皮肌炎(PM/DM)的临床特征,并与81例阴性组进行比较。结果本组中抗Jo-1抗体阳性占16.5%,抗Jo-1抗体阳性组出现肺间质病变(ILD)11例(68.75%)、肺部感染15例(93.75%)、和多关节炎/关节痛8例(50.00%)、肌肉活检异常3例(18.75%)、肌力异常4例(25.00%)、RF阳性5例(55.50%)、技工手4例(25.00%)、发热14例(87.50%)、皮肤硬肿5例(31.25%)与抗Jo-1抗体阴性组比较,差异显著(P<0.05)。结论在多发性肌炎/皮肌炎(PM/DM)中,抗Jo-1抗体阳性者有明显的肺间质病变、肺部感染、多关节炎、RF阳性、技工手、发热、皮肤硬肿等临床特征,提高对Jo-1抗体综合征的认识,早期诊断,早期治疗,提高生存率。Objective To investigate the clinical features of polymyositis （PM） / Dermatomyositis （DM） and its relationship with anti - Jo - 1 antibody. Methods Clinical characteristics of 16 PM/DM cases with anti Jo - 1 antibody were compared with that of 81 PM/DM ca- ses without anti Jo - 1 antibody. Results In Anti Jo - 1 antibody positive group, palmorary infections were most frequently presented （ 93.75 % ）, followed by fever （ 87.50% ）, interstitial pneumonia（ 68.75 % ） , arthritis （ 55.50% ）, RF positive （55.50%）, swollen skin （31.25%）, muscle weakness （25.00%）, mechanic＇ s hand （25.00%）, abnormal muscle biopsy（ 18.75% ）, and it was significantly different for these features when compared with those of anti Jo - 1 antibody negative group. Conclusion Anti Jo - 1 antibody was showed to be associated with some clinical features of PM/DM.

关 键 词：抗JO-1抗体 多发性肌炎 皮肌炎 

分 类 号：R593.26[医药卫生—内科学]