生长抑素垂体后叶素及奥美拉唑三联治疗肝硬化食管胃底静脉曲张破裂出血疗效观察  

Effect of somatostatin, pituitrin and omeprazole on esophago - gastric fundus variceal bleedings in liver cirrhosis patients

作　　者：张骏[1] 贾宝辉[2] 徐龙[1] 徐贞秋[1] 幸泽斌[1] 

机构地区：[1]南昌大学附属传染病医院南昌市第九医院肝二科,江西330002 [2]南昌大学第四附属医院

出　　处：《中国急救医学》2009年第10期935-937,共3页Chinese Journal of Critical Care Medicine

摘　　要：目的评价生长抑素、垂体后叶素及奥美拉唑三联治疗肝硬化食管胃底静脉曲张破裂出血的疗效和不良反应。方法将157例肝硬化并食管胃底静脉曲张破裂出血患者随机分为三组：生长抑素、垂体后叶素及奥美拉唑三联（A）组77例，单用生长抑素（B）组42例及单用垂体后叶素（C）组38例，记录并比较三组药物治疗上消化道出血的疗效及不良反应。结果A组治疗食管胃底静脉曲张破裂出血有效率93％（72／77），明显高于B组78％（33／42）和C组55％（21／38），P均〈0．05。A组药物不良反应发生率为22％，明显低于C组（44％，P〈0．05），而与B组差异无统计学意义（14％，P〉0．05）。结论生长抑素、垂体后叶素及奥美拉唑三联治疗肝硬化食管胃底静脉曲张破裂出血安全、有效。Objective To investigate the clinical effects and adverse events of somatostatin, pituitrin and omeprazole in the patients with esophageal and gastric variceal bleeding and liver cirrhosis. Methods 157 patients with esophageal and gastric variceal bleeding and liver cirrhosis were divided into three groups ： group A （ 77cases ） , group B （ 42 cases ） and group C （ 38 cases ）. Group A received somatostatin, pituitrin and omeprazole. Group B were treated with somatostatin while Group C were treated with pituitrin. The clinical effects and adverse events of patients were recorded and investigated. Results The effective rate of group A was significantly higher than that of group B （93% vs 78%, P 〈 0.05） and that of group C（93% vs 55% , P 〈0.05）. The rate of adverse events of group A was significantly lower than that of group C （22% vs 44%, P 〈 0.05）. There were no statistical differences in the rate of adverse events between group A and group B （22% vs 14%, P 〉 0. 05 ）. Conclusion Somatostatin, pituitrin and omeprazole is an effective and safe drug for esophageal and gastric variceal bleeding in liver cirrhosis patients.

关 键 词：生长抑素 垂体后叶素 奥美拉唑 肝硬化 食管胃底静脉曲张破裂出血 

分 类 号：R973.1[医药卫生—药品] R573.2[医药卫生—药学]