替米沙坦对老年高血压胰岛素抵抗患者超敏C-反应蛋白水平的影响  

Effect of telmisartan on the concentration of high-sensitivity C-reactive protein in elderly patients with hypertension and insulin resistance

作　　者：付军[1] 王桂贤[1] 张国成[1] 侯文丽[1] 冷吉燕[1] 董国霞[1] 何娜[2] 

机构地区：[1]吉林大学第一医院老年病科,吉林长春130021 [2]解放军军事医学科学院11所

出　　处：《中国老年学杂志》2009年第18期2290-2291,共2页Chinese Journal of Gerontology

基　　金：吉林省科技厅资助项目(200508)

摘　　要：目的通过应用替米沙坦治疗老年高血压伴胰岛素抵抗(IR)患者,观察其对超敏C反应蛋白(hs-CRP)水平变化及对胰岛素敏感性的影响。方法老年高血压病伴IR患者60例,随机分为替米沙坦组和硝苯地平组各30例,治疗4w,测定治疗前后血压、空腹血糖、真胰岛素、hs-CRP、血脂、血尿酸和IR指数、胰岛β细胞功能指数。结果两组基线资料相匹配。替米沙坦组治疗后血压、真胰岛素、hs-CRP及HOMA-IR和HOMA-islet指数较治疗前和硝苯地平组均明显下降,具有显著性差异(P<0.05)。结论替米沙坦除了具有强效、稳定降低血压的作用外,还具有改善IR胰岛β细胞功能、降低hs-CRP水平的作用。Objective To explore the effect of telmisartan on the concentration of high-sensitivity C-reactive protein（hs-CRP） and insulin sensitivity in elderly patients with hypertension and insulin resistance（IR）. Methods 60 elderly patients with hypertension and IR were randomly divided into telmisartan （n = 30 ） and CCB groups （n = 30 ）, to observe the changes of blood pressure, fasting blood glucose, true insulin, hs-CRP, lipid, uric acid（ UA）, IR index and the islet β-cell function index after treatment for 4 w. Results The baseline data of two groups were matched. The blood pressure, true insulin, hs-CRP, HOMA-IR and HOMA-islet index had significantly decreased than those before treatment and in CCB group（ P 〈 0. 05 ）. Conclusions Telmisartan could improve IR and isletβ cell function, down-regulate the level of hs-CRP, besides effectively and steadily reduce the blood pressure.

关 键 词：高血压病 替米沙坦 胰岛素抵抗 HS-CRP PPAR-Γ 

分 类 号：R587[医药卫生—内分泌] R592[医药卫生—内科学]