自主研发体外自动除颤器的实验研究  

Defibrillation efficacy of a newly developed automated external defibrillator in a swine ventricular tachycardia/fibrillation model

作　　者：惠杰[1] 谷云飞[1] 邬小玫[2] 朱宗成[1] 宋建平[1] 杨向军[1] 刘志华[1] 蒋廷波[1] 方祖祥[2] 蒋文平[1] 

机构地区：[1]苏州大学第一附属医院心内科,215006 [2]复旦大学电子信息工程学院

出　　处：《中华心血管病杂志》2009年第9期845-848,共4页Chinese Journal of Cardiology

摘　　要：目的评价自主设计和研制体外自动除颤器（AED）对室性心动过速（室速）／心室颤动（室颤）识别的敏感性、特异性以及除颤效果。方法应用交流电刺激实验动物诱发室速／室颤，记录并分析AED对室速／室颤的识别以及除颤放电的整个过程，评价其诊断识别和除颤性能。结果诱颤96次，除颤145次，记录心电数据167段次，共计103 740s。室速／室颤的识别准确性为99．5％，敏感性为98．2％，特异性为99．6％。除颤成功率和除颤能量呈正相关，成功除颤的能量阈值为（78．75±35．64）J，电量阈值为（0．11±0．04）C，电压阈值为（1216．67±260．87）V。结论自主研制的AED具有较高的识别敏感性和特异性，其识别和除颤效果达到或优于国外同类产品。Objective The aim of this study was to evaluate the recognition and defibrillation efficiency of a newly developed automated external defibrillator （AED）. Method Ventricular tachycardia （VT） /ventricular fibrillation （VF） was induced by alternating current （50 Hz） through an electrode placed on apex of right ventricle in 23 anesthetized swine and recorded, recognized and defibrillated by a newly developed AED. Results A total of 96 VF was induced and 145 defibrillations were recorded. We analyzed available 167 electrocardiosignal with a total length of 103 740 seconds. The accuracy, sensitivity and the specificity of the AED on VT/VF recognition are 99. 5% ,98. 2% and 99. 6% , respectively. The success rate of defibrillation was 33.4% which increased in proportion to defibrillation energy. The defibrillation threshold of energy is 29. 10-116. 91 （78.75 ± 35. 64 ） J, the defibrillation threshold of electric quantity is （0. 11±0. 04 ）C and the defibrillation threshold of voltage is （1216.67± 260. 87 ）V. Conclusions This newly developed AED has high sensitivity and the specificity on recognizing VT/VF. The lower success rate of defibrillation of this AED is associated with the low defibrillation energy during defibrillation which needs to be improved on further development.

关 键 词：电抗休克 心室颤动 体外自动除颤器 

分 类 号：R686[医药卫生—骨科学]