基于组蛋白甲基化信息的H2A.Z和H2A核小体识别  

IDENTIFICATION OF H2A.Z AND H2A NUCLEOSOMES BASED ON HISTONE METHYLATION INFORMATION

作　　者：陈伟[1] 罗辽复[1] 

机构地区：[1]内蒙古大学物理科学与技术学院,呼和浩特010021

出　　处：《生物物理学报》2009年第4期269-274,共6页Acta Biophysica Sinica

基　　金：国家自然科学基金资助项目(90403010)~~

摘　　要：组蛋白H2A的变体H2A.Z在基因的表达过程中发挥着重要的作用。根据H2A.Z和H2A核小体中组蛋白甲基化修饰方式的不同,作者应用多样性增量二次判别方法(increment of diversity with quadratic discriminant,IDQD)成功地对H2A.Z和H2A核小体进行了识别,说明了以组蛋白甲基化信息作为特征参数的IDQD模型对H2A.Z和H2A核小体识别的有效性。通过计算DNA序列的柔性,发现H2A.Z核小体对应的DNA序列的平均柔性比常规H2A核小体对应的DNA序列的平均柔性弱。H2A.Z, the variant of H2A, plays a crucial role in the process of gene expression. Based on the different patterns of histone methylation between H2A.Z and H2A nucleosomes, the method of Increment of Diversity with Quadratic Discriminant （IDQD） was successfully applied to the classification of H2A.Z and H2A nucleosomes. The results demonstrated the effectiveness of the IDQD model. By computing sequence flexibility, the average flexibility of DNA wrapped around the H2A.Z nucleosome was found to be significantly smaller than that around the H2A.Z nucleosome.

关 键 词：H2A H2A.Z 组蛋白甲基4JC 多样性增量二次判别法 

分 类 号：Q61[生物学—生物物理学]