肌肉注射黄体酮致局部不良反应相关因素分析  

Analysis of Risk Factors of Adverse Reactions Caused by Injection of Progesterone

作　　者：孙青苗[1] 金彦[1] 陈捷[2] 沈浣[3] 蔡林[1] 

机构地区：[1]北京大学人民医院皮肤科,北京100044 [2]北京大学人民医院临床流行病科,北京100044 [3]北京大学人民医院生殖中心,北京100044

出　　处：《中国药物应用与监测》2009年第5期300-302,共3页Chinese Journal of Drug Application and Monitoring

摘　　要：目的:分析肌肉注射黄体酮所致局部不良反应的相关因素,明确不良反应的发生原因。方法:回顾性分析2007年5月-2008年7月在我院行IVF-ET术后肌肉注射黄体酮的152例患者的临床资料,对所得数据采用SPSS13.0统计软件包进行统计学分析。结果:将152例患者分为两组,A组78例应用黄体酮每次6支(10mg·mL-1),出现注射反应19例,人工性脂膜炎9例;而B组74例应用黄体酮每次3支(20mg·mL-1),仅1例出现注射反应,无人工性脂膜炎。结论:肌肉注射黄体酮发生不良反应可能与黄体酮溶媒量或溶媒质量相关,可采用局部治疗。Objective： To analyze the possible causes of adverse reactions following intramuscular injection of progesterone. Methods： Clinical data of 152 patients were retrospectively investigated, who received intramuscular progesterone after undergoing in vitro fertilization-embryo transfer （IVF-ET） from May 2007 to July 2008 in our hospital. The data were analyzed with SPSS13.0. Results： 152 Patients were divided into two groups. 78 Patients in group A received progesterone of 10 mg·mL^-1, among them 19 had injection reactions and 9 had factitial panniculitis. 74 Patients in group B received progesterone of 20 mg·mL^-1, only 1 had injection reaction and no one had factitial panniculitis. Conclusion： The adverse reactions of progesterone were related to the solvent volume of progesterone and the quality of solvent being made by the manufacturers. The local treatment was effective.

关 键 词：黄体酮 不良反应 人工性脂膜炎 

分 类 号：R595.3[医药卫生—内科学]