通光藤中一个新C_(21)甾体成分  

One new C_(21) steroid from canes of Marsdenia tenacissima

作　　者：李建绪[1] 李华[2] 陈娜[1] 张莉[2] 陈燕 高美华[2,3] 

机构地区：[1]青岛市市立医院,山东青岛266071 [2]广东省药品检验所,广东广州510180 [3]雷允上药业有限公司,江苏苏州215011

出　　处：《中草药》2009年第9期1349-1352,共4页Chinese Traditional and Herbal Drugs

摘　　要：目的研究通光藤Marsdenia tenacissima的化学成分。方法采用硅胶柱色谱法及ODS柱色谱法进行分离纯化,依据理化性质和光谱数据鉴定化合物结构。结果从通光藤的70%乙醇提取物中分离得到了4个C21甾体化合物,分别鉴定为11α,12β-二-O-2-甲基丁酰基-通光藤苷元B(Ⅰ)、11α-O-2-甲基丁酰基-12β-O-乙酰基-通光藤苷元B(Ⅱ)、通光藤苷H(Ⅲ)和marsdenosideA(Ⅳ)。结论化合物Ⅰ为新化合物,命名为通光藤苷O(tenacis-sosideO)。Objective To study chemcial constituents in the canes of Marsdenia tenacissirna. Methods Chemical constituents were isolated and purified by silica gel and ODS column chromatography. The structures were identified by means of physico-chemical and spectral data. Results From the 70% ethanol extract of the material, four compounds were isolated. Their structures were identified as 11α,12β-di-O-2- methylbutyryl-tenacigenin B （ Ⅰ ）, 11α-O-2-methylbutyryl-12β-O-acetyl-tenacigenin B （Ⅱ ）, tenacissoside H （Ⅲ）, and marsdenoside A （Ⅳ）, respectively. Conclusion Compound Ⅰ is a new C21 steroid compound, named tenacissoside O.

关 键 词：通光藤 C21甾体 11α 12β-二-O-2-甲基丁酰基-通光藤苷元B 通光藤苷O 

分 类 号：R284.1[医药卫生—中药学]