肢端肥大症与高血压临床诊治  

Acromegaly and Hypertension

作　　者：岑晶[1] 顾锋[1] 

机构地区：[1]中国医学科学院中国协和医科大学北京协和医院内分泌科,北京100730

出　　处：《中国实用内科杂志》2009年第10期887-890,共4页Chinese Journal of Practical Internal Medicine

摘　　要：肢端肥大症是一种临床少见的内分泌疾病,可引起心血管、呼吸系统及代谢异常等并发症,其中高血压常见,导致患者病死率增加。其发病机制目前尚未达到共识,本文结合相关文献,综述肢大患者高血压发病率、危险性及其可能发病机制。肢大现代治疗目标主要是采用合适的方法使生化指标尽早达标,将病死率降低至正常人水平。针对肢大并发高血压,提出目前包括手术、放疗及药物的肿瘤本身治疗及高血压相关治疗。经治疗后部分患者血压下降,但控制生长激素(GH)与胰岛素样生长因子-1(IGF-1)至正常范围内非常重要。Acromegaly is a rare clinical endocrine disorder related to systematic complications such as cardiovascular, respiratory and metabolic disorders which determine its prognosis. Hypertension is the main complication resulting in the increased frequency of morbidity. The mechanism of hypertension in acromegaly is still no real consensus. In this review, we examine the prevalence and danger of hypertension in acromegalic patients and discuss the clinical and experimental mechanisms on the cardiovascular system in order to define the possible pathogenetic factors involved in the development and/or maintenance of high arterial blood pressure in acromegaly. The modern object of acromegalic treatment is normalization of morbidity and the treatment of pituitary tumor involve surgery,medication and radiation. Besides, blood pressure control is also demanded. The lowering of blood pressure observed in a proportion of hypertensive acromegalics, and the normalization of serum GH and IGF-1 level is of great importance.

关 键 词：肢端肥大症 高血压 垂体 腺瘤 生长激素 

分 类 号：R5[医药卫生—内科学]