隐结构模型及其在中医证候研究中的应用  

Latent structure models and their application in TCM syndrome research*

作　　者：王天芳[1] 张连文[2] 赵燕[1] 王燚[2] 吴秀艳[1] 袁世宏[1] 王智瑜[1] 杜彩凤[1] 徐雯洁 于春光[1] 陈弢[2] 潘建文[2] 王庆国[1] 

机构地区：[1]北京中医药大学基础医学院,北京100029 [2]香港科技大学 [3]北京市中医院

出　　处：《北京中医药大学学报》2009年第8期519-526,共8页Journal of Beijing University of Traditional Chinese Medicine

基　　金：国家重点基础研究发展计划(973计划)资助项目(No.2003CB517106;No.2003CB517101);香港研究资助局项目(No.622307;No.622408)

摘　　要：用隐结构法研究中医证候的基本思想是运用隐结构模型对临床流行病学调查获取的、未经过医生事先辨证的症状数据进行多维聚类分析,为证候的规范化、标准化研究提供较为客观的依据。在系统阐述隐结构分析及隐结构模型诠释的原理和工具的基础上,提出了隐结构法应用于中医证候研究的意义及步骤,并以抑郁症的隐结构模型为例,示范了隐变量和隐类诠释的方法和步骤,以期为今后从病证结合角度进行类似的研究提供参考。The basic idea to apply latent structure models in TCM syndrome research is to first collect data on the occurrence of symptoms （but without TCM syndrome diagnosis） through epidemiological survey, and then perform multidimensional clustering analysis on the data using latent structure models. The objective is to provide an objective and quantitative basis for the standardization of TCM syndrome differentiation. In this paper, we systematically explain the conceptual advances on the underlying principles and potentials of the approach, and the technical advances on the interpretation of latent structure models. The exposition is in terms of a study on depression so as to provide an example of reference for future research.

关 键 词：隐结构模型 证候 抑郁症 

分 类 号：R241[医药卫生—中医诊断学]