下呼吸道感染不动杆菌属流行和药敏变迁分析  

Analysis of the transition of Acinetobacter sp' prevalence in low respiratory tract infection and their drug sensitivity

作　　者：王文晶[1] 黄茂 王艳丽 周敏 赵旺胜 梅亚宁 乔岩[1] 孙丽华[1] 

机构地区：[1]南京医科大学附属南京第一医院呼吸科 [2]南京医科大学第一附属医院呼吸科,江苏南京210006 [3]南京医科大学第一附属医院检验科,江苏南京210006

出　　处：《现代生物医学进展》2009年第16期3089-3091,3094,共4页Progress in Modern Biomedicine

摘　　要：目的:分析近年来南京医科大学第一附属医院不动杆菌属的流行情况及耐药现状,为临床合理应用抗菌药物提供指导依据。方法:收集2004年-2008年南京医科大学第一附属医院下呼吸道感染住院病人痰培养结果为不动杆菌的数据,用WHONET5.3软件统计分析。结果:2004年-2008年该院下呼吸道感染住院病人痰培养为不动杆菌属占所有病原体比例为7.0%-9.2%,占革兰阴性菌比例为13.9%-17.5%。革兰阴性菌中,不动杆菌始终排在前三位。不动杆菌对亚胺培南、美罗培南和头孢哌酮/舒巴坦较敏感。结论:下呼吸道感染病原体中不动杆菌占据越来越大的比例,减少医源性感染、合理选择的抗菌药物对于降低死亡率、提高医疗资源利用率至关重要。Objective： This study was to investigate the situation of Acinetobacter sp＇ prevalence in low respiratory tract infection and their drug resistance and to provide guidance for the reasonable usage of antibacterial agents. Methods： To collect and analyze the data of Acinetobacter sp from the sputum specimens of inpatients in the First Affiliated Hospital of NJMU with low respiratory tract infection from 2004 to 2008 with the software WHONET5.3. Results： From 2004 to 2008, the ratio of Acinetobacter sp to all pathogens cultivated from the sputum of inpatients with low respiratory tract infectio was 7.0%-9.2% while the ratio of Acinetobacter sp to Gram-nega- tive bacilli was 13.9%-17,5%. Acinetobacter sp is the third prevalence bacterial in Gram-negative bacilli. Acinetobacter sp were sensitive to Imipenem, Meropenem and Cefoperazone/Sulbactam. Conclusion： The isolation rate of Acinetobacter sp was higher and higher in low respiratory tract infection, and the ways to improve the cure rate were to decrease nosocomial infection and increase the utilizing ratio of the resource.

关 键 词：下呼吸道感染 不动杆菌 耐药性 

分 类 号：R563[医药卫生—呼吸系统]