亲水凝胶骨架缓释片释药机制评价方法的研究进展  

Progress on Evaluation Methods for Release Mechanism of Hydrophlic Gel Matrix Sustained-Release Tablets

作　　者：王博[1] 张来华[1] 李苑新[1] 朱盛山[1] 

机构地区：[1]广东药学院中药开发研究所,广东广州510006

出　　处：《中国医药工业杂志》2009年第10期782-786,共5页Chinese Journal of Pharmaceuticals

基　　金：国家自然科学基金(30672670);国家科技部"十一五"支撑(2006BAIOPB08-02)

摘　　要：亲水凝胶骨架缓释片的释药过程与相转变过程、凝胶层屏障及区域前沿移动行为密切相关。综述了近几年研究其释药机制的方法。The phase transition, barrier function and front movement of the gel layer are closely related to drug release process of hydrophlic gel matrix sustained-release tablets. The evaluation methods for release mechanism of hydrophlic gel matrix sustained-release tablets in recent years are reviewed.

关 键 词：亲水凝胶骨架缓释片 释药机制 凝胶层 前沿移动 综述 

分 类 号：R944.4[医药卫生—药剂学]