CS/PLLA/TPP纳米微胶囊的制备及体外释放  

Preparation of Chitosan/L-polylactic Acid/sodium Tripolyphosphate Microcapsules and in vitro release

作　　者：付静[1] 杨文静[2] 何磊[1] 何农跃[1] 

机构地区：[1]东南大学公共卫生学院,江苏南京210096 [2]东南大学生物科学与医学工程学院,江苏南京210096

出　　处：《化工时刊》2009年第9期26-28,共3页Chemical Industry Times

基　　金：国家自然科学基金(批准号:60121101;60571032;90606027);国家重点基础研究发展计划--纳米研究重大科学研究计划项目课题(批准号:2007CB936104)资助

摘　　要：主要考察负载雷帕霉素（Rapaymcin，RAPA）的壳聚糖（Chitosan，CS）微球在加入左旋聚乳酸（L—polylactic acid，PLLA）时的载药量，包封率及在不同溶剂中的缓释性能。采用三聚磷酸钠（Sodium tripolyphosphate，TPP）作为离子交联剂，应用离子凝聚法制备CS／PLLA／TPP纳米微胶囊，用透射电镜和粒径分析仪进行了表征。结果表明：离子凝胶法可以得到粒径约300—400nm均匀分散的壳聚糖纳米微胶囊；微胶囊包封率可达84．25％，微胶囊载药量可达30．22％，雷帕霉素在不同溶剂中的缓释性能有很大不同。The RAPA - loading efficiency of CS/PLLA/TPP nano - sized microcapsules after addition of the PL- hA. and the release performance of the CS/PLLA/TPP nano - sized microcapsules under different conditions were studied. CS/PLLA/TPP nano - sized microcapsules were prepared by ionic gelation of CS with TPP. The obtained CS nano - sized microcapsules were characterized with the scanning electron microscope （SEM） and the palticle size analyzer. The average diameter of the obtained nano - sized microcapsules was around 300 - 400 rim, and a homogeneous size distribution and good dispersion were observed. The efficiency of encapsulation reached as high as 84.25% and the RAPA - loading reached 30.22%, and the distinct release performances of the CS nano - sized microcapsules in the different solutions is discussed.

关 键 词：壳聚糖 载药量 缓释溶液 

分 类 号：R944[医药卫生—药剂学]