疏肝理气法对功能性消化不良大鼠下丘脑 胃 血浆胃泌素的影响  

The Effect of the Method of Soothing the Liver and Regulating qi on Gastrin in Hypothalamus,Gastric Antrum and Plasma of Functional Dyspepsia Model Rats

作　　者：凌江红[1] 韦连明[1] 张钰琴[1] 王道刚[1] 梁纲[2] 陈业强[1] 刘耀利[2] 李勇杰[2] 

机构地区：[1]广西医科大学第一附属医院中医科,广西南宁530021 [2]广西医科大学病理生理学教研室,广西南宁530021

出　　处：《辽宁中医杂志》2009年第10期1812-1813,共2页Liaoning Journal of Traditional Chinese Medicine

基　　金：广西科学基金资助项目(桂科青0447039)

摘　　要：目的:观察疏肝理气法对实验性功能性消化不良大鼠下丘脑、胃、血浆胃泌素的影响。方法:40只大鼠随机分为正常组、模型组、柴胡疏肝散组、吗丁啉组,每组10只,以夹尾激惹刺激法制作功能性消化不良大鼠模型,并分别给予生理盐水、柴胡疏肝散水煎剂、吗丁啉溶液灌胃,观察各组大鼠下丘脑、胃、血浆胃泌素变化。结果:柴胡疏肝散组大鼠除下丘脑外,其胃、血浆胃泌素含量显著高于模型组大鼠(均P<0.05),与吗丁啉组无显著差别(均P>0.05)。结论:疏肝理气法升高胃和血浆胃泌素可能是其治疗消化不良的作用机制之一。Objective ： To explore the effects of the method of soothing the liver and regulating qi on Gastrin in Hypothalamus, Gastric Antrum and Plasma of functional dyspepsia model rats. Methods：40 rats were randomly divided into normal group,model group,chaihushugansan group and domperidone group （each n = 10）. The functional dyspepsia model was established by constantly squeezing their tails and mean while saline, chaihushugansan decoction and domperidone suspension were administered respectively to three groups by gavage. The Gastrin in Hypothalamus, Gastric Antrmn and Plasma were measured four weeks later. Results：Gastrin in Gastric Antrum and Plasma of Chaihushugansan group were significantly higher than those of model group（both P 〈 0. 05 ） No significant difference in compare with those of domperidone group （ both P 〉 0. 05 ）. Conclusion： The method of soothing the liver and regulating qi has the function of increasing the content of gastrin in gastric antrum and plasma,which may be one of its therapeutic mechanisms on functional dyspepsia.

关 键 词：疏肝理气 消化不良 大鼠 胃泌素 

分 类 号：R825.7[医药卫生—临床医学]