狼疮性肾炎患者抗中性粒细胞胞浆抗体的检测及临床意义  

Anti-neutrophil Cytoplasm Antibody Test in Patients with Lupus Nephrtis and Its Clinical Significance

作　　者：杨玉芹[1] 张迎梅[1] 王兵[1] 

机构地区：[1]南京医科大学附属淮安第一医院检验科,江苏淮安223300

出　　处：《现代检验医学杂志》2009年第5期130-131,共2页Journal of Modern Laboratory Medicine

摘　　要：目的探讨狼疮性肾炎（LN）与血清抗中性粒细胞胞浆抗体（ANCA）阳性之间的关系。方法采用免疫印迹法（IB）检测110例有轻度扣明显肾损害的LN患者及30例健康体检者血清ANCA，并对结果进行统计学分析。结果LN患者轻度肾损害者ANCA阳性率（32．00％）和肾损害明显者ANCA阳性率（58．30％）均高于正常对照组（0.00％）。肾损害明显的患者ANCA（58．30％）亦高于轻度肾损害者（32．00%）。结论血清ANCA检测与LN密切相关，它可以作为LN诊断的参考指标。Objective To observe the relationship between lupus nephritis （LN） and anti-neutrophil cytoplasm antibody （ANCA）. Methods ANCA was detected by immunoblotting（IB） in sera from 110 patients with light or severe damage in the kidney and 30 healthy blood donors. The results were analyzed statistically. Results The positive rate of ANCA in patients with light（32.00%） or severe damage（58.30%） in the kidney was higher than that in healthy people（0. 00%）. The positive rate of ANCA in patients with severe damage in the kidney（58.30%） was higher than that in patients with light kidney damage（32.00%）. Conclusion ANCA are related to lupus nephritis and taken as reference for diagnosis.

关 键 词：狼疮性肾炎 抗中性粒细胞胞浆抗体 免疫印迹法 

分 类 号：R593.242[医药卫生—内科学] R392.11[医药卫生—临床医学]