不同人群胃蛋白酶原水平检测分析  

Serum pepsinogen level in health persons and patients with chronic gastric disease or stomach cancer

作　　者：朱岚[1] 黄飚[1] 张珏[1] 张艺[1] 周彬[1] 王柯[1] 马智鸿[1] 蒋叶华[1] 

机构地区：[1]江苏省原子医学研究所,无锡214063

出　　处：《中国公共卫生》2009年第10期1216-1217,共2页Chinese Journal of Public Health

基　　金：江苏省社会发展基金项目(BS2006015)

摘　　要：目的探讨正常及高危人群胃蛋白酶原（PG）水平的分布情况。方法采用时间分辨荧光免疫分析法（TRFIA）测定人血清PG样本并对比分析PGⅠ、PGⅡ和PGⅠ/PGⅡ与胃黏膜病变的关系。结果正常体检人群血清PGⅠ、PGⅡ和PGⅠ/PGⅡ的95%正常参考值范围分别为60-252μg/L,≤27.9μg/L和≥6μg/L;男性PGⅠ、PGⅠ/PGⅡ水平明显高于女性（P〈0.05）;PGⅡ水平差异无统计学意义;PGⅠ/PGⅡ水平随年龄增高而降低;PGⅠ水平在慢性浅表性胃炎（CSG）组—慢性萎缩性胃炎（CAG）组—胃癌（GCa）组的变化过程中逐渐降低,GCa组在PGⅠ≥240μg/L和≤60μg/L均有较高的检出率,GU组PGⅠ≥240μg/L的异常检出率明显高于其他组（P〈0.05）;CAG和GCa组血清PGⅠ/PGⅡ比值明显低于其他组（P〈0.05）;血清PGⅠ≥240μg/L或≤60μg、PGⅠ/PGⅡ≤6可作为GCa较为合适的筛查界定值。结论血清PG水平明显高偏离正态分布,有明显的性别差异,与胃黏膜损伤程度有关。Objective To investigate serum pepsionogen（PG） level in health persons and patients with chronic gastric disease or stomach cancer. Methods Serum PG level was detected by TRFIA. The correlation between the levels of serum PG I , PG II and PG I/PG II and the mucosal changes in the patients with chronic gastropathy was analyzed. Results The normal reference range of PG I , PG II and PG I/PG II was 60 - 252 μg/L,≤27.9μL/L and PG I/PG ii ≥ 6, respectively. The level of serum PG I ,PG I/PG II in male were significantly higher than those of in female（ P 〈 0. 05 ）. PG II had no significant difference in gender. There was a significant decrease in PG I/PG II ratio along with the increase of age. The level of serum PG I gradually reduced with the progress of chronic superficial gastritis （CSG）, chronic atrophic gastritis（CAG） ,and gastric cancer（GCa）. The SCa group showed a high detection rate of PG I ≥240μg/L and ≤60 μg/L. The possitive rate of PG I ≥240 μg/L was significantly higher in gastric ulcer（GU） group. The ratio of serum PG I/PG II in CAG group and SCa group were signcficantly lower than other groups. Serum PG I ≥240 or ≤60 μg/L and PG I/PG II ≤ 6 were good cut-off value for the screen of GCa. Conclusion The serum PG level showed a skew distribution and significantly rose with sex and gastric mucosal changes.

关 键 词：胃蛋白酶原(PG) 正常人群 高危人群 时间分辨荧光免疫分析(TRFIA) 慢性胃病 

分 类 号：Q55[生物学—生物化学]