2-(4,6-二甲基-2-嘧啶巯基)乙酰芳胺的合成及其生物活性的初步研究  

SYNTHESES AND PRELIMINARY BIOLOGICAL ACTIVITIES TEST OF 2 (4,6 DIMETHYL 2 PYRIMIDINYLTHIO)ACETAMIDES

作　　者：李斌[1] 刘洋[1] 郭桂文[1] 刘武成[1] 

机构地区：[1]化工部沈阳化工研究院

出　　处：《化学研究与应用》1998年第5期501-503,共3页Chemical Research and Application

摘　　要：许多乙酰芳胺类化合物具有优异的生物活性，例如除草剂苯噻草胺，可抑制细胞生长和分裂，防除稻田中禾本科杂草［１］；杀菌剂甲霜灵可防治作物霜霉病［２］。本文将具有多种生物活性的嘧啶基团引入到乙酰芳胺结构中［３］，合成下列１０个未见文献报道的标题化合物Ⅰ，通...Ten novel 2 (4,6 dimethyl 2 pyrimidinylthio) acetamides were prepared by reactions of 2 chloro acetamides with 2 mercapto 4,6 dimethylpyrimidine in butanone.Their structures were identified by IR, 1HNMR and MS.At 50mg/L in vitro.The title compounds Ⅰshowed good fungicidal activities at 1000mg/L in vivo compound “If” showed 72% and 82% control of erysiphe graminis and puccinia recondita respectively.

关 键 词：巯基 二甲基嘧啶 乙酰胺 合成 农药 乙酰芳胺 

分 类 号：O626.41[理学—有机化学] TQ45[理学—化学]