内脏脂肪蓄积与血尿酸和代谢综合征的关系  

The Relation between Accumulation of Visceral Fat and Serum Uric Acid and Metabolic Syndrome

作　　者：蒋建家[1] 孙炳庆[1] 庄玉君[1] 苏劲波[1] 林振忠[1] 黄文森[1] 

机构地区：[1]福建医科大学附属泉州第一医院内分泌科,泉州362000

出　　处：《福建医科大学学报》2009年第4期327-330,共4页Journal of Fujian Medical University

摘　　要：目的研究内脏脂肪蓄积与血尿酸、代谢综合征(MS)的相关性。方法选取2006-2007年就诊的肥胖患者122例,分为内脏型肥胖组[体质量指数(BMI)≥25.0 kg/m2,男性腰围≥85 cm或女性腰围≥80 cm,内脏脂肪面积≥100 cm2]与皮下型肥胖组(BMI≥25.0 kg/m2,男性腰围≥85 cm或女性腰围≥80 cm,内脏脂肪面积<100 cm2)。采用CT测定腹部脂肪分布,并测定血清胰岛素、血尿酸、血糖等指标。结果内脏型肥胖组血尿酸水平高于皮下型肥胖组[(450.37±56.58)μmol/Lvs(329.19±94.00)μmol/L,P<0.01]。内脏型肥胖组MS发生率高于皮下型肥胖组(64.1%vs31.8%,P<0.01)。直线相关分析显示腰围与内脏脂肪面积、皮下脂肪面积、BMI、收缩压、舒张压、稳态模型评估的胰岛素抵抗指数(HOMA-IR)、血尿酸、肌酐、甘油三酯、总胆固醇呈正相关;内脏脂肪与腰围、BMI、收缩压、舒张压、HOMA-IR、血肌酐、尿酸、甘油三酯、总胆固醇呈正相关。多元逐步回归分析显示BMI、皮下脂肪、甘油三酯、肌酐、尿酸可用作腰围的解释变量;尿酸、甘油三酯、收缩压可作为内脏脂肪的解释变量。结论内脏脂肪蓄积与血尿酸水平及MS发生密切相关。Objective To study the correlaiton of accumulation of visceral fat and serum uric acid and metabolic syndrome（MS）. Methods 122 cases of obese outpatients from year 2006 to 2007,with male waist circumference greater than 85cm and that of females greater than 80cm,were enrolled in the study.These patients have never been given hypoglycemic,hypolipidemic,hydragogue,or anti-hyperuricemic agents.Pateients with essential hypertension treated with ARBs were excluded.Abdominal fat distribution was measured with computed tomography （CT scan）. Serum insulin , serum uric acid and plasma glucose levels were also measured. The subjects were divided into visceral obesity （BMI≥25.0Kg/m^2, male waist circumference≥ 85cm and that of females ≥80cm,and visceral fat area≥100cm2）, subcutaneous obesity （BMI≥25.0Kg/m^2 ,male waist circumference ≥85cm and that of females≥80cm, and visceral fat area≥100cm^2） according to the BMI, waist circumference and visceral fat area. Results The level of serum uric acid in visceral obesity is higher than that in subcutaneous obesity, [（450.37±56.58） μmol/L vs （329.19±94） μmol/L, P〈0.01]; the incidence of MS in visceral obesity is also higher than that in subcutaneous obesity significant （64.1% vs 31.8%, P〈0.01）. Linear correlation showed that waist circ- umference was positively correlated with visceral fat area, subcutaneous fat area, BMI, SBP, DBP, HOMA-IR, serum uric acid, creatinine, serum triglyceride, serum total cholesterol level. Visceral fat area was positively correlated with waist circumference, BMI, SBP, DBP, HOMA-IR, creatinine, serum uric acid, serum triglyceride and serum total cholesterol level. Stepwise multiple regression analysis showed that BMI, subcutaneous fat area, serum triglyceride, creatinine, serum uric acid were significant explanatory variables for waist circumference levels, and serum uric acid, serum triglyceride, SBP were significant explanatory variables for visceral fat area. Conclusion The accumulation of viscera

关 键 词：代谢综合征X 肥胖症 高尿酸血症 内脏 脂肪类 

分 类 号：R589.25[医药卫生—内分泌]