热敏性高分子包裹的磁性微球的合成  

SYNTHESIS OF THERMOSENSITVE MAGNETIC POLYMER MICROSPHERES

作　　者：丁小斌[1] 孙宗华[1] 万国祥[1] 江英彦[2] 

机构地区：[1]中国科学院成都有机化学研究所 [2]中国科学院化学研究所

出　　处：《高分子学报》1998年第5期628-631,共4页Acta Polymerica Sinica

基　　金：国家自然科学基金

摘　　要：磁性高分子微球由于其在外加磁场作用下简单、快速易行的磁分离特性，其在细胞分离、固定化酶、靶向药物等领域的应用研究日益活跃，并显示出较好的应用前景［１］．有关文献报道了制备磁性微球的不同方法［２］．Ｎ异丙基丙烯酰胺（Ｎｉｓｏｐｒｏｐｙｌａｃｒｙｌａ...Fe 3O 4/P(St NIPAM) thermosensitive magnetic microspheres with core/shell structure were prepared by copolymerization of styrene(St) and N isopropylacrylamide(NIPAM) in the presence of Fe 3O 4 magnetic fluid in ethanol/water medium. The content of Fe 3O 4 is about 20～100mg/g in the microspheres. The hydrodynamic diameter of Fe 3O 4/ P(St NIPAM) is depended on temperature and shrank above the lower critical solution temperature (LCST) in water. Thermosensitive magnetic microspheres with average diameter size range from 5 to 100 μm were obtained by different reaction conditions.Higher initiator concentration formed larger Fe 3O 4/P(St NIPAM) microshpheres, Ethanol played important roles in the polymerization, while the stabilizer PEG has smaller effect for the size of Fe 3O 4/P(St NIPAM) microspheres.

关 键 词：磁流体 热敏性 磁性微球 SR NIPAM 磁分离 共聚 

分 类 号：O658.9[理学—分析化学]