RNAi在抗肿瘤研究中的应用  

Progress in the Application of RNAi in Cancer Therapy

作　　者：郁兵[1] 淡飞妮[1] 罗雯[1] 

机构地区：[1]西安文理学院生命科学系,西安710065

出　　处：《科学技术与工程》2009年第20期6114-6121,共8页Science Technology and Engineering

基　　金：陕西省教育厅专项科研计划(07JK371);西安文理学院自然科学专项基金资助

摘　　要：RNA干扰作用(RNA interferenc,RNAi)是近年来发现的一种由双链RNA(double-stranded RNA,dsRNA)引发的转录后基因沉默现象(post transcriptional gene silencing,PTGS)。随着RNAi作用机制的逐渐阐明,已被广泛应用于多种领域。它不但是研究基因功能的有力工具,而且为特异性基因治疗提供了新的技术手段。RNAi技术的进一步发展,为肿瘤基因治疗开拓了一条新的途径。本文介绍RNAi的作用机制与抗肿瘤应用的研究进展。RNA interference （RNAi） is a recently developed technique for post-transcriptional gene silencing induced hy introduction of double-stranded RNA （dsRNA）. In the progress of the study on RNA interference mechanisms, it has been widely used in many researching fields. It＇s not only be a powerful tool in gene functional research, but also provides a new technique for gene therapy. With development of RNAi technology there has been a new approach for gene therapy for cancers. The research progress in is introduced the mechanisms and application of RNAi in cancer therapy.

关 键 词：RNA干扰作用 小分子干扰RNA 双链RNA 基因沉默 

分 类 号：Q75[生物学—分子生物学]