脂质体模拟生物膜研究药物吸收  

Studies on Drugs Absorption Using Liposome to Simulate Biomembrane

作　　者：罗云敬[1] 沈含熙[1] 刘海涛[1] 孔德明[1] 

机构地区：[1]南开大学化学系

出　　处：《高等学校化学学报》1998年第11期1730-1734,共5页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金

摘　　要：应用膜模型脂质体研究了脂溶性药物水杨酸、水溶性药物维生素Ｂ６和头孢曲松钠、喹诺酮类抗菌素氟哌酸及抗癌药物阿霉素的吸收，并与细胞膜上的吸收情况作了比较．吸收曲线呈直线关系的水杨酸吸收依赖被动扩散．维生素Ｂ６的实验结果表明吸收依赖于细胞膜上的蛋白，是一种化学过程，吸收值不呈直线关系．头孢曲松钠的吸收方式是简单的扩散过程．氟哌酸在离子作用下扩散通过脂双层．阿霉素是在细胞核内核酸的牵引力作用下跨膜吸收．The absorptions of liposoluble salicylic acid, water soluble vitamin B 6, ceftriaxone, quinolone antibacteria norfloxacin and anticancer medicine doxorubicin were discussed by using liposome as biomembrane model and comparison with cell membrane. The absorption of salicylic acid whose absorption curve is linear depends on the passive diffusion. The experimental result of vitamin B 6 supports the opinion that the absorption of vitamin B 6 depends on proteins which lie in membranes. The absorption of vitamin B 6 is a chemical process, so absorption curve is nonlinear. The absorption mode of ceftriaxone is a simple diffusion. The absorption of norfloxacin depends on the effects of metal ions. Under the driving force of nucleic acid in cells, doxorubicin was absorbed through biomembrane.

关 键 词：脂质体 生物膜 药物吸收 模拟 抗癌药 阿霉素 

分 类 号：R965.2[医药卫生—药理学] R979.14[医药卫生—药学]