2-(4-氨酰基-2-噻唑基)-1,4-脱水-L-木糖醇及其氟代衍生物的构象研究  

Conformational Studies on 2 (4 Aminocarbonyl 2 thiazoyl) 1,4 anhydro L xylitols and Their Fluorine Derivatives

作　　者：张虎翼[1] 张亮仁[1] 马灵台 张礼和[1] 崔育新[1] 刘雪辉[1] 

机构地区：[1]北京医科大学药学院抗肿瘤药物研究室

出　　处：《高等学校化学学报》1998年第11期1767-1770,共4页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金

摘　　要：计算机分子模拟方法研究了２－（４－氨酰基－２－噻唑基）－１，４－脱水－Ｌ－木糖醇及其氟代衍生物的糖基构象．计算结果显示，６个碳核苷类似物的糖基构象均为Ｓ型．核磁共振谱和晶体Ｘ射线衍射结果与计算结果相吻合．Employing computer aided molecule simulation, the conformations of 2 (4 aminocarbonyl 2 thiazoyl) 1,4 anhydro L xylitols and their fluorine derivatives have been studied. The results obtained from calculation show that these novel isomeric C nucleosides favor the S conformation. NMR study and crystal X ray analysis of these compounds coincidentally point to S type furanose conformation.

关 键 词：构象 NMR 晶体 X射线分析 异碳核苷 核苷 

分 类 号：Q525.03[生物学—生物化学]