在有机溶剂中进行酶催化合成肽及肽类衍生物的研究进展  

Progress in Enzymatic Syntheses of Peptides and Peptide Derivatives in Organic Solvents

作　　者：邢国文[1] 叶蕴华[1] 李崇熙[1] 

机构地区：[1]北京大学化学与分子工程学院

出　　处：《高等学校化学学报》1998年第10期1602-1607,共6页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金

摘　　要：介绍了有机溶剂中含非天然组分的肽及肽类衍生物的酶催化反应。More attention has been focused on the enzymatic reaction in organic solvents in recent years. In this paper, syntheses of peptides and peptide derivatives containing unnatural constituent catalyzed by proteases and lipase were introduced. The influence of reaction conditions on the enzymatic synthesis and its application to the preparation of cyclopeptide and polypeptide were reviewed. The study of relationship between enzyme activity and its structure through modern spectroscopy was also discussed.

关 键 词：蛋白酶 酶催化反应 肽 肽类衍生物 有机溶剂 

分 类 号：Q514.302[生物学—生物化学]