微波辅助固相有机反应  

Microwave Assisting Solid Phase Organic Reaction Monitored by FTIR

作　　者：喻爱明[1] 张政朴[1] 杨华铮[1] 张春香[1] 刘准[1] 

机构地区：[1]南开大学元素有机化学国家重点实验室

出　　处：《高等学校化学学报》1998年第10期1608-1610,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金

摘　　要：固相有机合成是组合化学中构建化合物库的主要工具之一［１，２］，但是，由于它是连接在固相载体（如树脂等）上的试剂与溶解在有机溶剂中的试剂之间的反应，因此反应比较缓慢．考虑到微波技术对有机反应的协助作用，我们将微波技术应用到固相有机反应中，对比研究了微波...Microwave assisting the addition reaction of Wang resin bound secondary amine 1 and isocyanate was carried out for the first time. The reaction time course was determined by analyzing FTIR spectra obtained using the improved KBr pellet method by grinding down the resin beads prior to recording. The results showed that the reaction assisted by microwave was accomplished only in 12 min, while the reaction without microwave was completed in 210 min.

关 键 词：微波 树脂 固相有机合成 仲胺 异氰酸酯 加成 

分 类 号：O621.392[理学—有机化学]